Hemangiomatous造釉细胞瘤;一个独立的实体？”

IF 2.9 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Seminars in Diagnostic Pathology Pub Date : 2025-01-01 DOI:10.1053/j.semdp.2025.01.003

Roshna Sankar , Sharon John , Priya Devi , Saloni Verma , Priyanka Singh , Shalini Gupta

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引用次数: 0

摘要

成釉细胞瘤（AM）是一种局部侵袭性肿瘤，血管瘤性成釉细胞瘤（HA）是一种罕见的亚型，其特征是血管增生，主要发生在基质中，偶尔也发生在上皮成分中。我们报告一例32岁男性复发性下颌肿胀，组织病理学诊断为单囊性HA，间质和牙源性上皮岛均有血管，后者GLUT1阳性。回顾31例病例，发现男性偏好，下颌优势（89.74%），并与常规AM特征重叠。血凝素的血管形成归因于反应性、肿瘤性或血管生成机制，罕见的上皮受损伤提示异常的血管生成或血管模拟。需要进一步的研究来阐明其发病机制和临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Hemangiomatous ameloblastoma; A separate entity?”

Ameloblastomas (AM) are locally aggressive tumors, with hemangiomatous ameloblastoma (HA) being a rare subtype characterized by vascular proliferation, predominantly in the stroma but occasionally within the epithelial component. We report a case of a 32-year-old male with recurrent mandibular swelling, histopathologically diagnosed as unicystic HA, showing vascularity in both stroma and odontogenic epithelial islands with GLUT1 positivity in the latter. A review of 31 cases revealed a male predilection, mandibular dominance (89.74 %), and overlap with conventional AM features. Vascularity in HA is attributed to reactive, neoplastic, or angiogenic mechanisms, with rare epithelial involvement suggesting aberrant angiogenesis or vascular mimicry. Further research is essential to clarify its pathogenesis and clinical implications.

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来源期刊

Seminars in Diagnostic Pathology 医学-病理学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Each issue of Seminars in Diagnostic Pathology offers current, authoritative reviews of topics in diagnostic anatomic pathology. The Seminars is of interest to pathologists, clinical investigators and physicians in practice.