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IF 2 4区医学 Q2 PEDIATRICS

Children-Basel Pub Date : 2024-12-28 DOI:10.3390/children12010033

Leonardo Zoccante, Gianfranco Di Gennaro, Erika Rigotti, Marco Luigi Ciceri, Andrea Sbarbati, Marco Zaffanello

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引用次数: 0

摘要

背景/目的：自闭症谱系障碍（ASD）、注意缺陷多动障碍（ADHD）和抽动秽语综合征（TS）是症状重叠的神经发育障碍（NDD），这表明它们有部分共同的遗传起源。本研究调查了结缔组织相关疾病在 ASD、ADHD 或 TS 患者中的患病率。研究方法对 120 名 ASD、ADHD 或 TS 患者的家庭进行了问卷调查，收集了社会人口学数据，并检查了影响不同器官和系统的 10 种疾病。使用 STATA 16.0 进行统计分析，显著性水平设定为 5%。结果在 120 名患者中，48 人患有 ASD，36 人患有 ADHD，36 人患有 TS。与对照组（13.6%）相比，扁平足在 ASD（52.1%；OR 7.20；p < 0.001）、ADHD（52.8%；OR 6.73；p = 0.001）和 TS（38.9%；OR 3.70；p = 0.034）患者中更为常见。与对照组（18.2%）相比，患有 ASD（56.3%；OR 5.90；p = 0.001）、ADHD（50.0%；OR 4.11；p = 0.011）和 TS（58.3%；OR 5.35；p = 0.003）的人更容易出现过度敏感。近视和上睑下垂在多动症（30.6%）中更为常见。多动症患者可能有使用正畸装置的趋势（OR 3.20；p = 0.076）。扁平足和过敏症在父亲（分别为 31.0% 和 36.4%）、母亲（分别为 31.0% 和 15.2%）和患者（分别为 43.8% 和 55%）中也很常见。结论本研究的结果突显了 ASD、ADHD 和 TS 与扁平足、感觉过敏和其他结缔组织相关表现等特定躯体症状之间的显著关联。这些症状的家族发病率表明可能存在遗传基础，进一步支持了共同病因途径的假设。这些见解强调了跨学科研究的必要性，以探索神经发育性疾病和结缔组织疾病的关联机制，从而改进诊断和管理策略。

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Neurodevelopmental Disorders and Connective Tissue-Related Symptoms: An Exploratory Case-Control Study in Children.

Background/Objectives: Autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS) are neurodevelopmental disorders (NDDs) with overlapping symptoms, suggesting a partially shared genetic origin. This study investigates the prevalence of connective tissue-related conditions in individuals with ASD, ADHD, or TS. Methods: A questionnaire was administered to families of 120 individuals with ASD, ADHD, or TS, collecting sociodemographic data and examining 10 types of disorders affecting various organs and systems. Statistical analyses were performed using STATA 16.0, with the significance level set at 5%. Results: Among the 120 patients, 48 had ASD, 36 had ADHD, and 36 had TS. Flat feet were significantly more common in individuals with ASD (52.1%; OR 7.20; p < 0.001), ADHD (52.8%; OR 6.73; p = 0.001), and TS (38.9%; OR 3.70; p = 0.034) compared to controls (13.6%). Hypersensitivity was more frequent in individuals with ASD (56.3%; OR 5.90; p = 0.001), ADHD (50.0%; OR 4.11; p = 0.011), and TS (58.3%; OR 5.35; p = 0.003) compared to controls (18.2%). Myopia and ptosis were more common in ADHD (30.6%). There was a possible trend towards orthodontic device use in TS (OR 3.20; p = 0.076). Flat feet and hypersensitivity were also common in fathers (31.0% and 36.4%, respectively), mothers (31.0% and 15.2%), and patients (43.8% and 55%). Conclusions: The findings of this study highlight the significant associations between ASD, ADHD, and TS and specific physical symptoms, such as flat feet, sensory hypersensitivity, and other connective tissue-related manifestations. The familial prevalence of these symptoms suggests a potential genetic underpinning, further supporting the hypothesis of shared aetiological pathways. These insights underscore the need for interdisciplinary research to explore the mechanisms linking neurodevelopmental and connective tissue disorders, aiming to improve diagnosis and management strategies.

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.