{"title":"Predictive value of dynamic changes in inflammatory markers within 24 hours after mecha nical thrombectomy for outcome in patients with acute ischemic stroke.","authors":"Baorui Zhang, Aixin Liu, Tong Lai, Sisi Wang, Wei Lu, Mingxing Wang, Yonglei Zhu","doi":"10.1016/j.wneu.2025.123693","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study analyzes the factors influencing the 90-day prognosis of acute ischemic stroke (AIS) patients after mechanical thrombectomy (MT) and established a multidimensional risk model to predict postoperative 90-day outcomes.</p><p><strong>Methods: </strong>A retrospective analysis of clinical data was conducted for AIS patients who underwent MT at our hospital. A total of 111 patients who met the inclusion criteria were included in the study. Based on the modified Rankin Scale (mRS) scores from follow-up records at 3 months post-surgery, the patients were divided into a good prognosis group (88 cases, 79.28%), a poor prognosis group (23 cases, 20.72%). Receiver operating characteristic (ROC) curves were plotted using MedCalc software, and area under the curve (AUC) values were calculated to establish a risk prediction model, presented in the form of a nomogram.</p><p><strong>Results: </strong>Logistic regression analysis showed that C-reactive protein (T3) (p < 0.001), NIHSS score at admission (p = 0.001), and a history of atrial fibrillation (p = 0.004) were independent predictors of poor prognosis, while albumin (T2) (p = 0.008) was a protective factor for the 90-day outcome. The AUC values for these factors were 0.812, 0.760, 0.655, and 0.757, respectively. The AUC values of Normotu was 0.945. Calibration slope = 0.856, Calibration-in-the-Large ≈ 0, and Observed/Expected (O/E) ratio ≈ 1.</p><p><strong>Conclusion: </strong>Post-MT CRP levels, NIHSS score at admission, and a history of atrial fibrillation are significantly associated with poor prognosis in these patients. Moreover, higher levels of endogenous albumin are a protective factor for the 3-month prognosis of AIS patients after MT.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"123693"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.wneu.2025.123693","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Predictive value of dynamic changes in inflammatory markers within 24 hours after mecha nical thrombectomy for outcome in patients with acute ischemic stroke.
Background: This study analyzes the factors influencing the 90-day prognosis of acute ischemic stroke (AIS) patients after mechanical thrombectomy (MT) and established a multidimensional risk model to predict postoperative 90-day outcomes.
Methods: A retrospective analysis of clinical data was conducted for AIS patients who underwent MT at our hospital. A total of 111 patients who met the inclusion criteria were included in the study. Based on the modified Rankin Scale (mRS) scores from follow-up records at 3 months post-surgery, the patients were divided into a good prognosis group (88 cases, 79.28%), a poor prognosis group (23 cases, 20.72%). Receiver operating characteristic (ROC) curves were plotted using MedCalc software, and area under the curve (AUC) values were calculated to establish a risk prediction model, presented in the form of a nomogram.
Results: Logistic regression analysis showed that C-reactive protein (T3) (p < 0.001), NIHSS score at admission (p = 0.001), and a history of atrial fibrillation (p = 0.004) were independent predictors of poor prognosis, while albumin (T2) (p = 0.008) was a protective factor for the 90-day outcome. The AUC values for these factors were 0.812, 0.760, 0.655, and 0.757, respectively. The AUC values of Normotu was 0.945. Calibration slope = 0.856, Calibration-in-the-Large ≈ 0, and Observed/Expected (O/E) ratio ≈ 1.
Conclusion: Post-MT CRP levels, NIHSS score at admission, and a history of atrial fibrillation are significantly associated with poor prognosis in these patients. Moreover, higher levels of endogenous albumin are a protective factor for the 3-month prognosis of AIS patients after MT.
期刊介绍：
World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal''s mission is to:
-To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care.
-To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide.
-To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients.
Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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