健康和疾病中髓细胞的精氨酸代谢。

IF 7.9 2区 医学 Q1 IMMUNOLOGY
Eleftheria Karadima, Triantafyllos Chavakis, Vasileia Ismini Alexaki
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引用次数: 0

摘要

代谢灵活性是髓细胞功能的关键。精氨酸代谢对髓细胞反应的调节是不可或缺的。精氨酸产生一氧化氮(NO)对抗微生物和促炎症反应至关重要。相反,在NO产生分支和多胺合成分支之间依赖于精氨酸酶1 (ARG1)的开关可以下调炎症并促进组织稳态的恢复。肌酸代谢是能量供应的关键,而脯氨酸代谢是胶原合成所必需的。髓系ARG1在寄生虫病和癌症中也调节细胞外精氨酸可用性和T细胞反应。癌症、外科手术、败血症和慢性炎性疾病(如神经炎性疾病或关节炎)的持续炎症与髓细胞精氨酸代谢失调有关。在这里,我们回顾了目前关于精氨酸在不同骨髓细胞类型中的代谢的知识,如巨噬细胞、中性粒细胞、小胶质细胞、破骨细胞、肿瘤相关巨噬细胞(tam)、肿瘤相关中性粒细胞(ans)和髓源性抑制细胞(MDSCs)。对骨髓细胞中精氨酸代谢功能的深入了解将提高我们对几种疾病病理的认识,并可能为新的治疗应用奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arginine metabolism in myeloid cells in health and disease.

Metabolic flexibility is key for the function of myeloid cells. Arginine metabolism is integral to the regulation of myeloid cell responses. Nitric oxide (NO) production from arginine is vital for the antimicrobial and pro-inflammatory responses. Conversely, the arginase 1 (ARG1)-dependent switch between the branch of NO production and polyamine synthesis downregulates inflammation and promotes recovery of tissue homeostasis. Creatine metabolism is key for energy supply and proline metabolism is required for collagen synthesis. Myeloid ARG1 also regulates extracellular arginine availability and T cell responses in parasitic diseases and cancer. Cancer, surgery, sepsis and persistent inflammation in chronic inflammatory diseases, such as neuroinflammatory diseases or arthritis, are associated with dysregulation of arginine metabolism in myeloid cells. Here, we review current knowledge on arginine metabolism in different myeloid cell types, such as macrophages, neutrophils, microglia, osteoclasts, tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs) and myeloid-derived suppressor cells (MDSCs). A deeper understanding of the function of arginine metabolism in myeloid cells will improve our knowledge on the pathology of several diseases and may set the platform for novel therapeutic applications.

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来源期刊
Seminars in Immunopathology
Seminars in Immunopathology 医学-病理学
CiteScore
19.80
自引率
2.20%
发文量
69
审稿时长
12 months
期刊介绍: The aim of Seminars in Immunopathology is to bring clinicians and pathologists up-to-date on developments in the field of immunopathology.For this purpose topical issues will be organized usually with the help of a guest editor.Recent developments are summarized in review articles by authors who have personally contributed to the specific topic.
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