前瞻记忆表现及其静息状态功能连通性与个体记忆投诉相关。

IF 2 3区心理学 Q3 BEHAVIORAL SCIENCES

Neuropsychologia Pub Date : 2025-01-22 DOI:10.1016/j.neuropsychologia.2025.109082

Gulcan Ozturk , Emre Hari , Kardelen Yildirim , Ali Bayram , Zerrin Yildirim , Tamer Demiralp , Hakan Gurvit

{"title":"前瞻记忆表现及其静息状态功能连通性与个体记忆投诉相关。","authors":"Gulcan Ozturk , Emre Hari , Kardelen Yildirim , Ali Bayram , Zerrin Yildirim , Tamer Demiralp , Hakan Gurvit","doi":"10.1016/j.neuropsychologia.2025.109082","DOIUrl":null,"url":null,"abstract":"<div><div>This study aimed to investigate prospective memory (PM) in patients with memory complaints but without dementia (PWD) and correlate findings with resting-state functional connectivity (rsFC) alterations. We hypothesized that PM impairment would be evident at a certain relatively early point in the continuum and specific rsFC patterns would be the neuroimaging signature of this impairment.</div><div>Sixty PWD participated in the study. The Memory Screening Test for Intentions and the Virtual Week were used to assess PM. Using the participants' PM scores as a regressor, the rsFC for PM was analyzed by Network-Based Statistics (NBS). Participants were divided into high and low PM groups (HPMG, LPMG) according to their PM scores and then their neuropsychological scores, rsFC patterns, and CSF biomarker levels were compared. The effect of education on the relationship between connectivity and CSF Aβ<sub>42</sub> level was examined by moderation analysis.</div><div>Compared with HPMG, LPMG was impaired in both event- and time-based PM tasks, but the difference was more distinct in the event-based ones. While HPMG was more successful in event-based tasks than time-based ones, LPMG was not. As a result of NBS analysis, the middle frontal gyrus (MFG), supramarginal gyrus (SMG), and anterior cingulate cortex (ACC) were determined as central seeds. The HPMG's performance and connectivity were higher for most comparisons but had lower CSF Aβ<sub>42</sub> than LPMG and therefore was closer to the positivity threshold. When the education level was at the mean and above, there was a negative correlation between CSF Aβ<sub>42</sub> level and overall connectivity.</div><div>The connectivities of MFG, SMG, and ACC play an important role in PM performance in the PWD. In more advanced PM impairment, the impairment of spontaneous processes is more prominent. At the onset of amyloidosis, the cognitive reserve may compensate for cognitive impairment by increasing connectivity.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"208 ","pages":"Article 109082"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prospective memory performance and its resting-state functional connectivity correlates in individuals with memory complaints\",\"authors\":\"Gulcan Ozturk , Emre Hari , Kardelen Yildirim , Ali Bayram , Zerrin Yildirim , Tamer Demiralp , Hakan Gurvit\",\"doi\":\"10.1016/j.neuropsychologia.2025.109082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This study aimed to investigate prospective memory (PM) in patients with memory complaints but without dementia (PWD) and correlate findings with resting-state functional connectivity (rsFC) alterations. We hypothesized that PM impairment would be evident at a certain relatively early point in the continuum and specific rsFC patterns would be the neuroimaging signature of this impairment.</div><div>Sixty PWD participated in the study. The Memory Screening Test for Intentions and the Virtual Week were used to assess PM. Using the participants' PM scores as a regressor, the rsFC for PM was analyzed by Network-Based Statistics (NBS). Participants were divided into high and low PM groups (HPMG, LPMG) according to their PM scores and then their neuropsychological scores, rsFC patterns, and CSF biomarker levels were compared. The effect of education on the relationship between connectivity and CSF Aβ<sub>42</sub> level was examined by moderation analysis.</div><div>Compared with HPMG, LPMG was impaired in both event- and time-based PM tasks, but the difference was more distinct in the event-based ones. While HPMG was more successful in event-based tasks than time-based ones, LPMG was not. As a result of NBS analysis, the middle frontal gyrus (MFG), supramarginal gyrus (SMG), and anterior cingulate cortex (ACC) were determined as central seeds. The HPMG's performance and connectivity were higher for most comparisons but had lower CSF Aβ<sub>42</sub> than LPMG and therefore was closer to the positivity threshold. When the education level was at the mean and above, there was a negative correlation between CSF Aβ<sub>42</sub> level and overall connectivity.</div><div>The connectivities of MFG, SMG, and ACC play an important role in PM performance in the PWD. In more advanced PM impairment, the impairment of spontaneous processes is more prominent. At the onset of amyloidosis, the cognitive reserve may compensate for cognitive impairment by increasing connectivity.</div></div>\",\"PeriodicalId\":19279,\"journal\":{\"name\":\"Neuropsychologia\",\"volume\":\"208 \",\"pages\":\"Article 109082\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuropsychologia\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S002839322500017X\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BEHAVIORAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychologia","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002839322500017X","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

本研究旨在调查有记忆抱怨但无痴呆（PWD）患者的前瞻记忆（PM），并将结果与静息状态功能连接（rsFC）改变相关联。我们假设PM损伤在连续体的某个相对较早的点上是明显的，特定的rsFC模式将是这种损伤的神经影像学特征。60名残疾人士参加了这项研究。使用意向记忆筛选测验和虚拟周来评估PM。使用参与者的PM分数作为回归量，通过基于网络的统计（NBS）分析PM的rsFC。根据PM评分将参与者分为高PM组和低PM组（HPMG， LPMG），然后比较他们的神经心理评分、rsFC模式和CSF生物标志物水平。通过调节分析检验教育程度对连通性与脑脊液Aβ42水平的影响。与HPMG相比，LPMG在基于事件和时间的PM任务中均受到损害，但在基于事件的PM任务中差异更为明显。HPMG在基于事件的任务中比基于时间的任务更成功，而LPMG则不然。通过NBS分析，确定中额回（MFG）、边缘上回（SMG）和前扣带皮层（ACC）为中心种子。在大多数比较中，HPMG的表现和连通性更高，但脑脊液Aβ42比LPMG低，因此更接近阳性阈值。当受教育程度在平均及以上时，脑脊液a β42水平与整体连通性呈负相关。在PWD中，MFG、SMG和ACC的连通性对PM的绩效起着重要作用。在更晚期的PM损伤中，自发过程的损伤更为突出。在淀粉样变发病时，认知储备可能通过增加连通性来补偿认知损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Prospective memory performance and its resting-state functional connectivity correlates in individuals with memory complaints

This study aimed to investigate prospective memory (PM) in patients with memory complaints but without dementia (PWD) and correlate findings with resting-state functional connectivity (rsFC) alterations. We hypothesized that PM impairment would be evident at a certain relatively early point in the continuum and specific rsFC patterns would be the neuroimaging signature of this impairment.

Sixty PWD participated in the study. The Memory Screening Test for Intentions and the Virtual Week were used to assess PM. Using the participants' PM scores as a regressor, the rsFC for PM was analyzed by Network-Based Statistics (NBS). Participants were divided into high and low PM groups (HPMG, LPMG) according to their PM scores and then their neuropsychological scores, rsFC patterns, and CSF biomarker levels were compared. The effect of education on the relationship between connectivity and CSF Aβ₄₂ level was examined by moderation analysis.

Compared with HPMG, LPMG was impaired in both event- and time-based PM tasks, but the difference was more distinct in the event-based ones. While HPMG was more successful in event-based tasks than time-based ones, LPMG was not. As a result of NBS analysis, the middle frontal gyrus (MFG), supramarginal gyrus (SMG), and anterior cingulate cortex (ACC) were determined as central seeds. The HPMG's performance and connectivity were higher for most comparisons but had lower CSF Aβ₄₂ than LPMG and therefore was closer to the positivity threshold. When the education level was at the mean and above, there was a negative correlation between CSF Aβ₄₂ level and overall connectivity.

The connectivities of MFG, SMG, and ACC play an important role in PM performance in the PWD. In more advanced PM impairment, the impairment of spontaneous processes is more prominent. At the onset of amyloidosis, the cognitive reserve may compensate for cognitive impairment by increasing connectivity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neuropsychologia 医学-行为科学

CiteScore

5.10

自引率

3.80%

发文量

228

审稿时长

4 months

期刊介绍： Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.