虚弱对社区老年人抑郁、焦虑和孤独网络的调节作用。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-01-23 DOI:10.1016/j.jad.2025.01.118

Xinru Wang , Baoqi Zhu , JunPeng Li , Xiaoyan Li , Lane Zhang , Yibo Wu , Lili Ji

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The moderating effect of frailty on the network of depression, anxiety, and loneliness in community-dwelling older adults

Objectives

Comorbidities of depression, anxiety and loneliness may be more prevalent in frail older adults, which may lead to an accelerated deterioration of psychological symptoms. This study was aimed to assess the moderating effect of frailty on the network of depression, anxiety, and loneliness symptoms in community-dwelling older adults.

Methods

A sample of 4253 older adults were recruited from the Psychology and Behavior Investigation of Chinese Residents (PBICR). Frailty, depression, anxiety, and loneliness were assessed using the FRAIL scale, the Patient Health Questionnaire-9, the Generalized Anxiety Disorder 7-item scale, and the Three-Item Loneliness Scale, respectively. Covariates of age, gender, education level, living status, marital status, and monthly family income were also collected.

Results

The prevalence of combined depression, anxiety and loneliness was 36.49 % in (pre)frail (i.e., frail or prefrail) older adults. Using the moderated network model, we found that (pre)frail older adults were more likely to experience “sad mood”, “appetite changes”, and “feel left out” than non-frail older adults. In addition, (pre)frail older adults had stronger correlations between “feel left out” and “feel isolated from others”, “feel isolated from others” and “lack companionship”, “nervousness or anxiety” and “feel left out”, “nervousness or anxiety” and “feel isolated from others”, and “sleep difficulties” and “feel left out” than non-frail older adults, while non-frail older adults had stronger correlations between “feel worthlessness” and “psychomotor agitation/retardation” than (pre)frail older adults.

Conclusions

(Pre)frail older adults may experience more comorbidities of depression, anxiety and loneliness due to more symptoms and stronger correlations between specific symptoms in the network. Future studies should target these symptoms to eliminate comorbidities of depression, anxiety and loneliness in (pre)frail older adults.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.