肽基药物在临床应用中的最新进展、策略和未来展望。

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-01-01 DOI:10.1016/S1875-5364(25)60800-4

Yang Qimeng , Hu Zhipeng , Jiang Hongyu , Wang Jialing , Han Han , Shi Wei , Qian Hai

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引用次数: 0

摘要

基于多肽的疗法由于其有前景的治疗特性和增强的安全性，在癌症、糖尿病、细菌感染和神经退行性疾病的治疗中引起了相当大的兴趣。本文综述了多肽药物发现和开发的主要趋势，强调了旨在提高多肽稳定性、特异性和药代动力学特性的临床前策略。它评估了目前基于肽的药物在这些疾病中的应用和挑战，说明了基于肽的药物显示出巨大潜力的制药领域。此外，本文还对未来需要克服的障碍进行了分析，旨在为肽类药物的持续发展提供有价值的见解和参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances, strategies, and future perspectives of peptide-based drugs in clinical applications

Peptide-based therapies have attracted considerable interest in the treatment of cancer, diabetes, bacterial infections, and neurodegenerative diseases due to their promising therapeutic properties and enhanced safety profiles. This review provides a comprehensive overview of the major trends in peptide drug discovery and development, emphasizing preclinical strategies aimed at improving peptide stability, specificity, and pharmacokinetic properties. It assesses the current applications and challenges of peptide-based drugs in these diseases, illustrating the pharmaceutical areas where peptide-based drugs demonstrate significant potential. Furthermore, this review analyzes the obstacles that must be overcome in the future, aiming to provide valuable insights and references for the continued advancement of peptide-based drugs.

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.