{"title":"使用或不使用氯己定制剂非手术机械清创治疗种植体周围粘膜炎的效果。一项随机安慰剂对照临床试验","authors":"Gaetano Isola, Alessandro Polizzi, Maria Santagati, Angela Alibrandi, Vincenzo Iorio-Siciliano, Luca Ramaglia","doi":"10.1111/clr.14405","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>To evaluate the treatment of peri-implant mucositis (PM) using a nonsurgical submarginal peri-implant instrumentation (NSPI) with or without chlorhexidine (CHX) solutions.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Fifty-six patients (28 per group) were randomly assigned to the test (NSPI + 0.12% mouthwash and subgingival CHX irrigation plus tongue brushing with 1% CHX gel) or the control group (NSPI + placebo mouthwash and subgingival placebo irrigation plus tongue brushing with placebo gel). At baseline, 1, 3, 6 months, bleeding on probing (BOP), probing pocket depth (PPD), modified gingival index (mGI), modified plaque index (mPlI), full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), and the proportions of \n <i>Aggregatibacter actinomycetemcomitans</i>\n , \n <i>Porphyromonas gingivalis</i>\n , \n <i>Tannerella forsythia</i>, and \n <i>Treponema denticola</i>\n were recorded. The BOP reduction was set as a primary outcome. Data were analyzed to assess BOP reduction at a 6-month follow-up and to identify significant predictors of implant-site BOP through mixed generalized linear regression.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>After 6 months in both groups, a significant reduction of BOP, PD, mPlI, mGI, FMBS, and FMPS was noted (<i>p</i> < 0.05). However, at 6 months, the test group was more effective than the controls in reducing median BOP (∆values control/test: 39.3% [95% CI 37.4–42.3] vs. 48.7 [95% CI 46.5–51.2], <i>p</i> = 0.044), as well as mPlI (<i>p</i> = 0.041) and the proportion of \n <i>Treponema denticola</i>\n (<i>p</i> = 0.039). Moreover, the implant-sites BOP reduction was significantly influenced by test treatment (<i>p</i> < 0.001), history of periodontitis (<i>p</i> = 0.003), and a high number of cigarettes/day (<i>p</i> = 0.002), the proportion of \n <i>Porphyromonas gingivalis</i>\n (<i>p</i> = 0.021) and \n <i>Tannerella forsythia</i>\n (<i>p</i> = 0.032).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>NSPI + CHX showed better results compared to placebo in implant-sites BOP reduction. The high number of cigarettes/day and the proportion of \n <i>Porphyromonas gingivalis</i>\n and \n <i>T. forsythia</i>\n negatively influenced the BOP reduction in PM-treated patients.</p>\n </section>\n </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 5","pages":"566-577"},"PeriodicalIF":5.3000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14405","citationCount":"0","resultStr":"{\"title\":\"Effect of Nonsurgical Mechanical Debridement With or Without Chlorhexidine Formulations in the Treatment of Peri-Implant Mucositis. A Randomized Placebo-Controlled Clinical Trial\",\"authors\":\"Gaetano Isola, Alessandro Polizzi, Maria Santagati, Angela Alibrandi, Vincenzo Iorio-Siciliano, Luca Ramaglia\",\"doi\":\"10.1111/clr.14405\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>To evaluate the treatment of peri-implant mucositis (PM) using a nonsurgical submarginal peri-implant instrumentation (NSPI) with or without chlorhexidine (CHX) solutions.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Fifty-six patients (28 per group) were randomly assigned to the test (NSPI + 0.12% mouthwash and subgingival CHX irrigation plus tongue brushing with 1% CHX gel) or the control group (NSPI + placebo mouthwash and subgingival placebo irrigation plus tongue brushing with placebo gel). At baseline, 1, 3, 6 months, bleeding on probing (BOP), probing pocket depth (PPD), modified gingival index (mGI), modified plaque index (mPlI), full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), and the proportions of \\n <i>Aggregatibacter actinomycetemcomitans</i>\\n , \\n <i>Porphyromonas gingivalis</i>\\n , \\n <i>Tannerella forsythia</i>, and \\n <i>Treponema denticola</i>\\n were recorded. The BOP reduction was set as a primary outcome. Data were analyzed to assess BOP reduction at a 6-month follow-up and to identify significant predictors of implant-site BOP through mixed generalized linear regression.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>After 6 months in both groups, a significant reduction of BOP, PD, mPlI, mGI, FMBS, and FMPS was noted (<i>p</i> < 0.05). However, at 6 months, the test group was more effective than the controls in reducing median BOP (∆values control/test: 39.3% [95% CI 37.4–42.3] vs. 48.7 [95% CI 46.5–51.2], <i>p</i> = 0.044), as well as mPlI (<i>p</i> = 0.041) and the proportion of \\n <i>Treponema denticola</i>\\n (<i>p</i> = 0.039). Moreover, the implant-sites BOP reduction was significantly influenced by test treatment (<i>p</i> < 0.001), history of periodontitis (<i>p</i> = 0.003), and a high number of cigarettes/day (<i>p</i> = 0.002), the proportion of \\n <i>Porphyromonas gingivalis</i>\\n (<i>p</i> = 0.021) and \\n <i>Tannerella forsythia</i>\\n (<i>p</i> = 0.032).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>NSPI + CHX showed better results compared to placebo in implant-sites BOP reduction. The high number of cigarettes/day and the proportion of \\n <i>Porphyromonas gingivalis</i>\\n and \\n <i>T. forsythia</i>\\n negatively influenced the BOP reduction in PM-treated patients.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10455,\"journal\":{\"name\":\"Clinical Oral Implants Research\",\"volume\":\"36 5\",\"pages\":\"566-577\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-01-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14405\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oral Implants Research\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/clr.14405\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Implants Research","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/clr.14405","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Effect of Nonsurgical Mechanical Debridement With or Without Chlorhexidine Formulations in the Treatment of Peri-Implant Mucositis. A Randomized Placebo-Controlled Clinical Trial
Objectives
To evaluate the treatment of peri-implant mucositis (PM) using a nonsurgical submarginal peri-implant instrumentation (NSPI) with or without chlorhexidine (CHX) solutions.
Methods
Fifty-six patients (28 per group) were randomly assigned to the test (NSPI + 0.12% mouthwash and subgingival CHX irrigation plus tongue brushing with 1% CHX gel) or the control group (NSPI + placebo mouthwash and subgingival placebo irrigation plus tongue brushing with placebo gel). At baseline, 1, 3, 6 months, bleeding on probing (BOP), probing pocket depth (PPD), modified gingival index (mGI), modified plaque index (mPlI), full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), and the proportions of
Aggregatibacter actinomycetemcomitans
,
Porphyromonas gingivalis
,
Tannerella forsythia, and
Treponema denticola
were recorded. The BOP reduction was set as a primary outcome. Data were analyzed to assess BOP reduction at a 6-month follow-up and to identify significant predictors of implant-site BOP through mixed generalized linear regression.
Results
After 6 months in both groups, a significant reduction of BOP, PD, mPlI, mGI, FMBS, and FMPS was noted (p < 0.05). However, at 6 months, the test group was more effective than the controls in reducing median BOP (∆values control/test: 39.3% [95% CI 37.4–42.3] vs. 48.7 [95% CI 46.5–51.2], p = 0.044), as well as mPlI (p = 0.041) and the proportion of
Treponema denticola
(p = 0.039). Moreover, the implant-sites BOP reduction was significantly influenced by test treatment (p < 0.001), history of periodontitis (p = 0.003), and a high number of cigarettes/day (p = 0.002), the proportion of
Porphyromonas gingivalis
(p = 0.021) and
Tannerella forsythia
(p = 0.032).
Conclusions
NSPI + CHX showed better results compared to placebo in implant-sites BOP reduction. The high number of cigarettes/day and the proportion of
Porphyromonas gingivalis
and
T. forsythia
negatively influenced the BOP reduction in PM-treated patients.
期刊介绍：
Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.
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