IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Toxics Pub Date : 2025-01-09 DOI:10.3390/toxics13010046
Ziyi Qian, Chenxu Dai, Siyan Chen, Linjie Yang, Xia Huo
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引用次数: 0

摘要

挥发性有机化合物(VOC)与肥胖的健康风险有关,而混合挥发性有机化合物与内脏脂肪指标的关系仍不清楚。本研究共纳入了 2015 名来自美国国家健康与营养调查(NHANES)的成年人。研究采用了加权广义线性模型、受限立方样条线(RCS)、加权量化和(WQS)和贝叶斯核机器回归(BKMR)来评估挥发性有机化合物代谢物(mVOCs)与内脏脂肪指数(VAI)和脂质累积乘积(LAP)的关系。在单一暴露模型中,多种 mVOC 与 VAI 和 LAP 呈正相关,尤其是 N-乙酰基-S-(2-羧乙基)-L-半胱氨酸(CEMA)和 N-乙酰基-S-(N-甲基氨基甲酰基)-L-半胱氨酸(AMCC)。mVOC 与 VAI 和 LAP 的关系在以下人群中更为显著
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exposure to Volatile Organic Compounds in Relation to Visceral Adiposity Index and Lipid Accumulation Product Among U.S. Adults: NHANES 2011-2018.

Volatile organic compounds (VOCs) are associated with obesity health risks, while the association of mixed VOCs with visceral adiposity indicators remains unclear. In this study, a total of 2015 adults from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted generalized linear models, restricted cubic spline (RCS), weighted quantile sum (WQS), and Bayesian kernel machine regression (BKMR) were adopted to assess the association of VOC metabolites (mVOCs) with the visceral adiposity index (VAI) and lipid accumulation product (LAP). Multiple mVOCs were positively associated with the VAI and LAP in the single-exposure model, especially N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA) and N-acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC). The associations of mVOCs with VAI and LAP were more significant in <60-year-old and non-obese individuals, with interactions of CEMA with age and AMCC with obesity status. Nonlinear relationships between certain mVOCs and the VAI or the LAP were also observed. In the WQS model, co-exposure to mVOCs was positively correlated with the VAI [β (95%CI): 0.084 (0.022, 0.147)]; CEMA (25.24%) was the major contributor. The result of the BKMR revealed a positive trend of the association between mixed mVOCs and the VAI. Our findings suggest that VOC exposure is strongly associated with visceral obesity indicators. Further large prospective investigations are necessary to support our findings.

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来源期刊
Toxics
Toxics Chemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍: Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.
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