代谢-脂滴-核酸串扰调节产油红球菌的脂质储存和其他细胞过程。

IF 2.4 4区 生物学 Q4 CELL BIOLOGY
Héctor M. Alvarez, Mariana P. Lanfranconi, Martín A. Hernández
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引用次数: 0

摘要

属于分枝杆菌属和红球菌属的放线菌能够合成并在细胞内以脂滴(ld)的形式积累可变量的三酰基甘油(TAG)。脂肪在细胞中的储存能力是由脂肪生成和脂肪分解之间的平衡控制的。TAG的生物合成可能直接促进细菌细胞内LD的生长,而TAG的降解可能导致LD大小和脂质储存能力的降低。因此,必须精确调节LD的形成和转化,以维持平衡的脂质分布,将基因调控与细胞代谢状态相结合。在真核细胞中,ld已成为多种细胞反应的关键介质,包括脂肪酸运输和转录程序的调节。最近在分枝杆菌和红球菌中进行的研究表明,细胞中脂质代谢、ld和基因表达调控之间存在类似的串音机制。这篇综述将不同的研究结果整合在一个综合的框架中,以提供在tag积累的放线菌中发生“脂质代谢- lds -基因组DNA”串音的证据。我们提供的例子表明,细菌细胞进化出了检测脂质代谢物变化的传感机制,作为代谢状态的指标,并通过由ld相关蛋白介导的表观遗传样机制调整其转录谱。在这里,我们描述了这个耦合系统的分子相互联系,以及每个组成部分的主要作用,这些组成部分将细胞代谢状态的信息整合到产油细菌的脂肪生成、LD形成和转录的调节中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Metabolism-lipid droplet-nucleic acid crosstalk to regulate lipid storage and other cellular processes in oleaginous Rhodococcus bacteria

Metabolism-lipid droplet-nucleic acid crosstalk to regulate lipid storage and other cellular processes in oleaginous Rhodococcus bacteria

Actinobacteria belonging to Mycobacterium and Rhodococcus genera are able to synthesize and intracellularly accumulate variable amounts of triacylglycerols (TAG) in the form of lipid droplets (LDs). The lipid storage capacity of LDs in cells is controlled by the balance between lipogenesis and lipolysis. The growth of LDs in bacterial cells may be directly promoted by TAG biosynthesis, whereas TAG degradation might result in the reduction of LD sizes and lipid storage capacity. Therefore, LD formation and turnover have to be precisely regulated to maintain a balanced lipid distribution, coupling gene regulation with the metabolic state of the cell. In eukaryotic cells, LDs have emerged as critical mediators of diverse cellular responses, including fatty acid trafficking and modulation of transcriptional programs. Recent studies performed in mycobacteria and rhodococci suggested the existence of similar crosstalk mechanisms between lipid metabolism, LDs, and gene expression regulation in cells. This review connects and organizes results of different studies in a comprehensive framework for providing evidence of “lipid metabolism-LDs-genomic DNA” crosstalk occurring in TAG-accumulating actinobacteria. We provide examples indicating that bacterial cells evolved sensing mechanisms that detect lipid metabolites changes as indicators of metabolic states, and adapt their transcriptional profiles through epigenetic-like mechanisms mediated by LD-associated proteins. Here, we describe the molecular interconnections of this coupling system and the main role of each component that integrates the information about the cellular metabolic state into the regulation of lipogenesis, LD formation and transcription in oleaginous bacteria.

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来源期刊
Biology of the Cell
Biology of the Cell 生物-细胞生物学
CiteScore
5.30
自引率
0.00%
发文量
53
审稿时长
>12 weeks
期刊介绍: The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms. This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.
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