视网膜微血管密度和分形维数与青光眼的关系：来自英国生物银行的前瞻性研究。

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2024-11-28 DOI:10.1016/j.xops.2024.100661

Qi Chen MD , Suyu Miao MD , Yuzhe Jiang MD , Danli Shi MD, PhD , Weiyun You MD , Lin Liu MD, PhD , Mayinuer Yusufu MTI , Yufan Chen MD , Ruobing Wang MD, PhD

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引用次数: 0

摘要

目的：探讨视网膜微血管参数与青光眼的关系。设计：前瞻性研究。受试者：英国生物银行受试者，有眼底图像且无青光眼病史。方法：采用基于视网膜的微血管健康评估系统，利用眼底摄影的无创性，量化视网膜微血管参数，包括视网膜血管骨架密度（VSD）和分形维数（FD）。我们还使用倾向评分匹配（PSM）来配对青光眼患者和健康对照者。倾向评分匹配通过一个逻辑回归模型，卡尺为0.1，匹配比为1:4无替换。我们进行了单变量Cox回归分析，以连续和四分位数形式研究视网膜微血管参数与青光眼发生率之间的关系。主要结局指标：血管骨架密度、FD和青光眼。结果：在一项41 632名没有青光眼的参与者的研究中，在中位随访11.0年期间记录了482例青光眼。在psm后的Cox比例风险回归模型中，我们发现青光眼的发生与小动脉VSD（风险比[HR] = 0.24, 95%可信区间[CI] 0.11-0.52, P P = 0.007）、小动脉FD （HR = 0.24, 95% CI 0.10-0.60, P = 0.002）和静脉FD （HR = 0.31, 95% CI 0.12-0.85, P = 0.022）呈显著负相关。使用协变量的亚组分析显示，年龄≥60岁、不吸烟者、中度饮酒者以及高血压和近视患者表现出P值。结论：我们的研究发现视网膜VSD降低和FD降低与青光眼风险升高有关。财务披露：专有或商业披露可在本文末尾的脚注和披露中找到。

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Associations of Retinal Microvascular Density and Fractal Dimension with Glaucoma: A Prospective Study from UK Biobank

Objective

To explore the association between retinal microvascular parameters and glaucoma.

Design

Prospective study.

Subjects

The UK Biobank subjects with fundus images and without a history of glaucoma.

Methods

We employed the Retina-based Microvascular Health Assessment System to utilize the noninvasive nature of fundus photography and quantify retinal microvascular parameters including retinal vascular skeleton density (VSD) and fractal dimension (FD). We also utilized propensity score matching (PSM) to pair individuals with glaucoma and healthy controls. Propensity score matching was implemented via a logistic regression model with a caliper of 0.1 and a matching ratio of 1:4 no replacements. We conducted univariable Cox regression analyses to study the association between retinal microvascular parameters and incident glaucoma, in both continuous and quartile forms.

Main Outcome Measure

Vascular skeleton density, FD, and glaucoma.

Results

In a study of 41 632 participants without prior glaucoma, 482 cases of glaucoma were recorded during a median follow-up of 11.0 years. In the Cox proportional hazards regression model post-PSM, we found that incident glaucoma has significant negative associations with arteriolar VSD (hazard ratio [HR] = 0.24, 95% confidence interval [CI] 0.11–0.52, P < 0.001), venular VSD (HR = 0.34, 95% CI 0.15–0.74, P = 0.007), arteriolar FD (HR = 0.24, 95% CI 0.10–0.60, P = 0.002), and venular FD (HR = 0.31, 95% CI 0.12–0.85, P = 0.022). Subgroup analysis using covariates revealed that individuals aged ≥60 years, nonsmokers, moderate alcohol consumers, and those with hypertension and myopia exhibited P values <0.05 consistently prematching and postmatching, differing from other subgroups within this covariate.