牛奶和奶制品中黄曲霉毒素M1的流行和浓度：荟萃分析综述。

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Health Pub Date : 2025-01-24 DOI:10.1093/inthealth/ihaf002

Abdolreza Sotoodeh Jahromi, Mohammad Jokar, Arman Abdous, Mohammad Hasan Rabiee, Farzad Heydari Bahman Biglo, Vahid Rahmanian

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引用次数: 0

摘要

背景：黄曲霉毒素M1 （AFM1）是黄曲霉毒素B1的衍生物，是牛奶和乳制品中的重要污染物。在这项研究中，我们对所有现有的系统评价和荟萃分析研究进行了总括性回顾，以了解和总结牛奶和乳制品中AFM1的全球患病率和水平。方法：我们对2024年1月前发表的英文结构化综述和荟萃分析文章进行了系统综述，没有时间限制。文章来源于知名数据库，包括PubMed/MEDLINE、EMBASE、Scopus、Web of Science、CINAHL和Cochrane系统综述数据库。b谷歌Scholar的相关研究也被纳入。结果：所有乳制品中AFM1的总体流行率为66.2% (95% CI为60.6 ~ 71.9%)，具有较高的异质性（I²=99.7%，Q统计量=2221.03,p）。结论：加强动物饲料的调控，降低动物饲料中的黄曲霉毒素B1 (AFB1)，监测乳制品中AFM1的重要性，特别是原料奶和加热奶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prevalence and concentration of aflatoxin M1 in milk and dairy products: an umbrella review of meta-analyses.

Background: Aflatoxin M1 (AFM1) is a derivative of aflatoxin B1 and a significant contaminant of milk and dairy products. In this study, we implemented an umbrella review of all existing systematic reviews and meta-analyzing studies to apprise and summarize the worldwide prevalence and level of AFM1 in milk and dairy products.

Methods: We conducted a systematic review of structured review and meta-analysis articles published in English until January 2024, with no time limit. Articles were sourced from reputable databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL and the Cochrane Database of Systematic Reviews. Relevant studies from Google Scholar were also included.

Results: The overall prevalence of AFM1 in all dairy products was 66.2% (95% CI 60.6 to 71.9%), with high heterogeneity (I²=99.7%, Q statistic=2221.03, p<0.0001). The prevalence for specific dairy products was as follows: raw milk, 64.8% (95% CI 60.9 to 68.7%); pasteurized milk, 88.7% (95% CI 81.6 to 95.7%); sterilized milk, 71.0% (95% CI 67.2 to 74.8%); ultra-high temperature processing (UHT) milk, 67.9% (95% CI 64.9 to 70.9%); yogurt, 58.8% (95% CI 42.5 to 75.1%); doogh, 17.2% (95% CI 13.9 to 20.5%); and cheese 49.8% (95% CI 47.8 to 51.9%). The overall mean concentration of AFM1 across all dairy products was 57.22 ng/kg (95% CI 46.95 to 67.49), with significant heterogeneity (I²=99.7%, Q statistic=2221.03, p<0.0001). Mean AFM1 levels (ng/kg) for each dairy product were as follows: raw milk, 52.51 (95% CI 40.96 to 64.05); pasteurized milk, 71.14 (95% CI 48.81 to 93.47); sterilized milk, 60.10 (95% CI 30.90 to 89.30); UHT milk, 82.57 (95% CI 35.30 to 129.85); yogurt, 46.74 (95% CI 24.27 to 69.21); and doogh, 41.60 (95% CI 32.60 to 50.60).

Conclusions: In total, these results highlight the importance of increasing the regulation of animal feed, reducing aflatoxin B1 (AFB1) in animal feed, and monitoring AFM1 in dairy products, particularly raw and heated milk.

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.