比美珠单抗成功治疗严重持续性肢端皮炎1例报告。

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

SAGE Open Medical Case Reports Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI:10.1177/2050313X241311043

Lily Xu, Kaiyang Li, Eric Mutter, Annie Langley

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引用次数: 0

摘要

持续性埃洛珀肢端皮炎是一种罕见的脓疱性银屑病，影响肢端手指和脚趾，其特征是无菌脓疱的反复爆发，导致明显的疼痛和潜在的不可逆的指甲器官破坏。症状往往难以局部和全身治疗银屑病。本病例报告一名23岁健康女性，患有严重的持续肢端皮炎，10个指甲全部被破坏。使用Bimekizumab（一种抑制白细胞介素-17的单克隆抗体）治疗，2个月后改善50%，1年后所有指甲完全正常再生。这种药物耐受性良好，没有任何副作用的报道。这是第二例报道的使用比美珠单抗治疗持续肢端皮炎成功的病例，突出了其作为治疗这种具有挑战性和顽固性疾病的有效和安全选择的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Successful treatment of severe acrodermatitis continua of hallopeau with Bimekizumab: A case report.

Acrodermatitis continua of Hallopeau is a rare form of pustular psoriasis affecting the acral fingers and toes, characterized by recurrent eruptions of sterile pustules that lead to significant pain and potentially irreversible destruction of the nail apparatus. Symptoms are often refractory to topical and systemic therapies for psoriasis. This case report presents a healthy 23-year-old female with severe acrodermatitis continua of Hallopeau, destructing all 10 fingernails. Treatment with Bimekizumab, a monoclonal antibody that inhibits interleukin-17, led to 50% improvement by 2 months, and complete normal regrowth of all fingernails by 1 year. The medication was tolerated well without any reported side effects. This is the second reported case of successful acrodermatitis continua of Hallopeau treatment with Bimekizumab, highlighting its potential as an effective and safe option for this challenging and recalcitrant condition.

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来源期刊

SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.60

自引率

0.00%

发文量

320

审稿时长

8 weeks

期刊介绍： SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.