早期食管癌病变经内镜粘膜下剥离后预防食管狭窄是必要的,其周径比为75%-99%:回顾性病例分析。

IF 2.7 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Yong Gao, Jiao Zhu, Jianjun Li, Xue Peng, Xubiao Nie, Haiyan Zhao, Lifu Sheng, Chaoqiang Fan, Jianying Bai
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引用次数: 0

摘要

目的:内镜下粘膜剥离术(ESD)是目前治疗早期食管癌最有效的方法之一。我们进行了回顾性病例分析,以确定早期食管癌的特点,提示食管狭窄的预防措施。目的是为临床决策提供参考。方法:2011年1月至2018年12月,654例早期食管癌患者接受ESD治疗。从医院信息系统中收集患者的人口学特征、病变特征、有无预防措施、ESD术后食管狭窄并发症等临床信息。采用SPSS软件(23.0版)对数据进行统计学分析。结果:1。79例早期食管癌患者行ESD后出现食管狭窄。从接受ESD到首次出现狭窄的中位时间为27(17-43)天。79例患者中,47例患者在ESD术后1个月内出现狭窄,23例患者在ESD术后1 ~ 2个月内出现狭窄,9例患者在术后2个月以上出现狭窄。采取预防措施可显著降低病变周围比为75% ~ 99%的早期食管癌患者总体食管狭窄发生率(P)。结论:对于病变周围比为75% ~ 99%的早期食管癌病变,有必要采取措施预防ESD后食管狭窄。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Measures to prevent esophageal stenosis are necessary after endoscopic submucosal dissection for early esophageal cancer lesions with a circumferential ratio of 75%-99%: a retrospective case analysis.

Purpose: Endoscopic submucosal dissection (ESD) is currently one of the most curative treatments for early esophageal cancer. We conducted a retrospective case analysis to identify the characteristics of early esophageal cancer that indicate esophageal stenosis prevention measures. Our aim was to provide a reference for clinical decision-making.

Methods: Six hundred and fifty-four patients with early esophageal cancer treated with ESD were admitted to our hospital between January 2011 and December 2018.Clinical information such as patients' demographic characteristics, lesion features, preventive measures if any, and complications of esophageal stenosis after ESD were collected from the hospital information system. The data were statistically analysed by SPSS software (version 23.0).

Results: 1. Seventy-nine patients with early esophageal cancer suffered from esophageal stenosis after ESD. The median time from undergoing ESD to the first occurrence of stenosis was 27 (17-43) days. Specifically, among the 79 cases, 47 of them experienced stenosis within one month after ESD, and 23 cases experienced stenosis between 1 and 2 months after ESD, and 9 cases experienced stenosis more than 2 months after the operation.2. Taking preventive measures significantly reduced overall esophageal stenosis incidence in patients with early esophageal cancer with lesion circumferential ratio of 75%-99% (P < 0.05).3. Among patients with early esophageal cancer with 75%-99% circumferential proportion of lesions, the risk of esophageal stenosis within 2 months without prevention measures was 2.617(95% CI, 1.057-6.479) times higher than that with prevention measures.

Conclusion: It is necessary to take measures to prevent esophageal stenosis after ESD for early esophageal cancer lesions with a circumferential ratio of 75%-99%.

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来源期刊
Postgraduate Medical Journal
Postgraduate Medical Journal 医学-医学:内科
CiteScore
8.50
自引率
2.00%
发文量
131
审稿时长
2.5 months
期刊介绍: Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.
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