肝硬化患者真菌感染的时间趋势:2016-2020年回顾性队列研究

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Choday Silpa , Talal Alomar , Robert J. Wong
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引用次数: 0

摘要

背景:由于体液免疫和细胞免疫的异常,肝硬化患者易受感染。真菌感染与诊断延迟和高死亡率有关,这强调了在这一患者群体中进行真菌培养和保持高水平怀疑的重要性。方法:本回顾性队列研究分析了合并细菌和真菌感染再入院的肝硬化患者,并调查了结果,包括院内死亡率和医院资源利用率。数据来自2016年至2020年的全国再入院数据库(NRD)。医院总费用使用HCUP费用收费比文件计算,并根据美国医疗保健服务的消费者价格指数(CPI)进行通货膨胀调整,以2020年为参考年。NRD数据集缺乏诸如腹水细胞计数、使用的抗真菌/抗菌药物和治疗反应等细节,限制了可以获得的临床见解。结果:本研究分析了393,195例指数住院病例。其中,30天入境的102505人,90天入境的157079人。自发性细菌性腹膜炎(SBP) 30天和90天再入院人数分别为8478人和15690人。自发性真菌性腹膜炎(SFP) 30天和90天再入院分别为3106天和5798例。患者平均年龄57.9岁(标准差57.7 ~ 58.1)。30天时SBP的平均住院时间(LOS)为9.4天,而各种真菌感染的SFP为14.9至32.3天。在SFP中,曲霉的LOS最长。与收缩压相比,SFP的死亡率和住院费用都有所增加(P < 0.001)。SBP和SFP的30天总收费分别为42,258美元和51,739美元。SBP的30天再入院总费用为64,266,SFP为89,913。结论:与SBP相比,SFP有更高的死亡率、LOS和住院费用。在对抗生素无反应的患者的诊断检查中考虑SFP是很重要的。早期识别和使用抗真菌药物可改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temporal Trends of Fungal Infections in Cirrhotic Patients: A Retrospective Cohort Study 2016–2020

Background

Patients with cirrhosis are susceptible to infections due to abnormalities in humoral and cell-mediated immunity. Fungal infections are associated with delayed diagnosis and high mortality rates, emphasizing the importance of performing fungal cultures and maintaining elevated levels of suspicion in this patient population.

Methods

This retrospective cohort study analyzes cirrhotic patients readmitted with bacterial and fungal infections and investigates outcomes, including in-hospital mortality and hospital resource utilization. Data was acquired from the Nationwide Readmission Database (NRD) from 2016 to 2020. Total hospital costs were calculated using HCUP Cost-to-Charge Ratio files and adjusted for inflation based on the Consumer Price Index (CPI) for medical care services in the U.S., with 2020 as the reference year. The NRD dataset lacks details like ascitic fluid cell counts, antifungal/antibacterial drugs used, and treatment responses, limiting the clinical insights that can be derived.

Results

The study analyzed 393,195 index hospitalizations. Among these, 102,505 account for 30-day and 157,079 account for 90-day readmissions. The 30-day and 90-day readmissions for spontaneous bacterial peritonitis (SBP) are 8478 and 15,690 respectively. The 30-day and 90-day readmissions for spontaneous fungal peritonitis (SFP) are 3106 and 5798 respectively. The mean age of patients was 57.9 years (standard deviation between 57.7 and 58.1). The mean length of stay (LOS) for SBP at 30 days is 9.4 days, while SFP has ranged from 14.9 to 32.3 days for various fungal infections. Aspergilloses have the longest LOS among SFP. There is an increased rate of mortality as well as hospital charges with SFP compared to SBP (P < 0.001). The 30-day index admission total charges for SBP are $42,258 and SFP are $51,739. The 30-day readmission total charges for SBP are 64, 266 and for SFP 89,913.

Conclusions

There is increased mortality, LOS, and hospital costs for SFP compared to SBP. It is important to consider SFP in the diagnostic workup for patients who do not respond to antibiotics. Early recognition and administration of antifungals can be associated with improved outcomes.
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来源期刊
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.90
自引率
16.70%
发文量
537
审稿时长
64 days
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