{"title":"99mtc -半乳糖人血清白蛋白SPECT/CT预测肝切除术后肝衰竭的定量评价。","authors":"Yukinori Okajima, Shin Yanagisawa, Akira Yamada, Tsuyoshi Notake, Akira Shimizu, Yuji Soejima, Yasunari Fujinaga","doi":"10.1097/RLU.0000000000005648","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the predictive ability of 99m Tc-galactosyl human serum albumin SPECT/CT quantitative parameters for posthepatectomy liver failure (PHLF).</p><p><strong>Methods: </strong>Sixty-eight patients who underwent 99m Tc-galactosyl human serum albumin scintigraphy as a preoperative examination for hepatectomy between July 2021 and December 2023 were prospectively evaluated. The patients were divided into PHLF and non-PHLF groups. The clearance index (HH15) and receptor index (LHL15) were calculated from planar images. Quantitative parameters for the total liver (SUV max , SUV mean , peak SUV [SUV peak ], functional liver volume [FLV], SUV mean × FLV), remnant liver (r-SUV max , r-SUV mean , r-SUV peak , r-FLV, and r-SUV mean × r-FLV), and r-FLV/FLV were calculated from SPECT/CT images. The areas under the curve (AUCs) of parameters from planar images and SPECT/CT parameters of the total and remnant livers were calculated to evaluate the predictive ability of PHLF.</p><p><strong>Results: </strong>PHLF occurred in 9 patients. AUC of r-FLV was significantly higher than that of HH15 (0.93; 95% confidence interval [CI], 0.84-0.99 vs 0.66; 95% CI, 0.46-0.84; P = 0.026) and LHL15 (0.93; 95% CI, 0.84-0.99 vs 0.72; 95% CI, 0.55-0.86; P = 0.043). AUC of r-SUV mean × r-FLV was significantly higher than that of HH15 (0.90; 95% CI, 0.80-0.97 vs 0.66; 95% CI, 0.46-0.84; P = 0.037). There were no significant differences between the AUC of other SPECT/CT, r-FLV/FLV, and planar image parameters.</p><p><strong>Conclusions: </strong>r-FLV can predict PHLF more accurately than HH15 or LHL15.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"404-409"},"PeriodicalIF":9.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quantitative Evaluation of 99m Tc-Galactosyl Human Serum Albumin SPECT/CT for the Prediction of Posthepatectomy Liver Failure.\",\"authors\":\"Yukinori Okajima, Shin Yanagisawa, Akira Yamada, Tsuyoshi Notake, Akira Shimizu, Yuji Soejima, Yasunari Fujinaga\",\"doi\":\"10.1097/RLU.0000000000005648\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the predictive ability of 99m Tc-galactosyl human serum albumin SPECT/CT quantitative parameters for posthepatectomy liver failure (PHLF).</p><p><strong>Methods: </strong>Sixty-eight patients who underwent 99m Tc-galactosyl human serum albumin scintigraphy as a preoperative examination for hepatectomy between July 2021 and December 2023 were prospectively evaluated. The patients were divided into PHLF and non-PHLF groups. The clearance index (HH15) and receptor index (LHL15) were calculated from planar images. Quantitative parameters for the total liver (SUV max , SUV mean , peak SUV [SUV peak ], functional liver volume [FLV], SUV mean × FLV), remnant liver (r-SUV max , r-SUV mean , r-SUV peak , r-FLV, and r-SUV mean × r-FLV), and r-FLV/FLV were calculated from SPECT/CT images. The areas under the curve (AUCs) of parameters from planar images and SPECT/CT parameters of the total and remnant livers were calculated to evaluate the predictive ability of PHLF.</p><p><strong>Results: </strong>PHLF occurred in 9 patients. AUC of r-FLV was significantly higher than that of HH15 (0.93; 95% confidence interval [CI], 0.84-0.99 vs 0.66; 95% CI, 0.46-0.84; P = 0.026) and LHL15 (0.93; 95% CI, 0.84-0.99 vs 0.72; 95% CI, 0.55-0.86; P = 0.043). AUC of r-SUV mean × r-FLV was significantly higher than that of HH15 (0.90; 95% CI, 0.80-0.97 vs 0.66; 95% CI, 0.46-0.84; P = 0.037). There were no significant differences between the AUC of other SPECT/CT, r-FLV/FLV, and planar image parameters.</p><p><strong>Conclusions: </strong>r-FLV can predict PHLF more accurately than HH15 or LHL15.</p>\",\"PeriodicalId\":10692,\"journal\":{\"name\":\"Clinical Nuclear Medicine\",\"volume\":\" \",\"pages\":\"404-409\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/RLU.0000000000005648\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RLU.0000000000005648","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Quantitative Evaluation of 99m Tc-Galactosyl Human Serum Albumin SPECT/CT for the Prediction of Posthepatectomy Liver Failure.
Purpose: To evaluate the predictive ability of 99m Tc-galactosyl human serum albumin SPECT/CT quantitative parameters for posthepatectomy liver failure (PHLF).
Methods: Sixty-eight patients who underwent 99m Tc-galactosyl human serum albumin scintigraphy as a preoperative examination for hepatectomy between July 2021 and December 2023 were prospectively evaluated. The patients were divided into PHLF and non-PHLF groups. The clearance index (HH15) and receptor index (LHL15) were calculated from planar images. Quantitative parameters for the total liver (SUV max , SUV mean , peak SUV [SUV peak ], functional liver volume [FLV], SUV mean × FLV), remnant liver (r-SUV max , r-SUV mean , r-SUV peak , r-FLV, and r-SUV mean × r-FLV), and r-FLV/FLV were calculated from SPECT/CT images. The areas under the curve (AUCs) of parameters from planar images and SPECT/CT parameters of the total and remnant livers were calculated to evaluate the predictive ability of PHLF.
Results: PHLF occurred in 9 patients. AUC of r-FLV was significantly higher than that of HH15 (0.93; 95% confidence interval [CI], 0.84-0.99 vs 0.66; 95% CI, 0.46-0.84; P = 0.026) and LHL15 (0.93; 95% CI, 0.84-0.99 vs 0.72; 95% CI, 0.55-0.86; P = 0.043). AUC of r-SUV mean × r-FLV was significantly higher than that of HH15 (0.90; 95% CI, 0.80-0.97 vs 0.66; 95% CI, 0.46-0.84; P = 0.037). There were no significant differences between the AUC of other SPECT/CT, r-FLV/FLV, and planar image parameters.
Conclusions: r-FLV can predict PHLF more accurately than HH15 or LHL15.
期刊介绍：
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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