原发性乳腺癌在18F-FES PET/CT和dbPET上的肿瘤内异质性预示了对化疗的异质性反应。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-06-01 Epub Date: 2025-01-20 DOI:10.1097/RLU.0000000000005660

Yurika Kitano, Kanae K Miyake, Yoichi Shimizu, Masahiro Kawashima, Yuji Nakamoto

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引用次数: 0

摘要

摘要：一名59岁的cT3N3M1浸润性乳腺癌（ER低阳性，PgR阳性，HER2阴性）患者接受了PET/CT和专用乳房PET扫描，使用18F-FDG和18f -氟雌二醇（18F-FES）。虽然大多数原发肿瘤区域显示低FES摄取，但也发现了高FES摄取的区域。在紫杉醇和贝伐单抗化疗后，18F-FDG PET/CT显示出良好的反应，但在预处理图像上FES摄取高的区域发现残留疾病。该病例表明，18F-FES PET可以描述原发肿瘤内的异质性，这与对后续化疗的异质性反应密切相关。

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Intratumoral Heterogeneity of Primary Breast Cancer on 18 F-FES PET/CT and dbPET Anticipated a Heterogeneous Response to Chemotherapy.

Abstract: A 59-year-old woman with cT3N3M1 invasive breast cancer (ER low positive, PgR positive, HER2 negative) underwent PET/CT and dedicated breast PET scans using 18 F-FDG and 18 F-fluoroestradiol ( 18 F-FES). While most primary tumor regions displayed low FES uptake, regions of high FES uptake were also identified. Following chemotherapy with the paclitaxel and bevacizumab, 18 F-FDG PET/CT demonstrated a favorable response, but residual disease was noted in areas with high FES uptake on the pretreatment images. This case illustrated that 18 F-FES PET can depict intratumoral heterogeneity within the primary tumor, which was strongly associated with a heterogeneous response to subsequent chemotherapy.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.