大规模生产用于谷胱甘肽响应t1 / t2开关磁共振成像和肿瘤治疗的超小Mn3O4纳米颗粒。

IF 4.6 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-01-23 DOI:10.1039/D4RA07224C
Qinghua Xie, Gaorui Zhang, Dawei Zhou, Hong Liu, Dexin Yu and Jiazhi Duan
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引用次数: 0

摘要

与多组分治疗方案相比,综合多功能的个体化治疗具有相当大的临床应用前景。研究开发了具有超小尺寸(4nm)和量产能力的Mn3O4纳米颗粒,具有肿瘤综合磁共振成像(MRI)和治疗双重功能。Mn3O4纳米晶体的高价态使其能够与谷胱甘肽(GSH)分子发生敏感反应,并具有良好的分解能力,这进一步诱导了独特的、有利的、可变的t1关闭和t2打开的MRI特性。此外,在肿瘤微环境中,超小的Mn3O4纳米颗粒与高水平GSH反应,可诱导响应性增强的可变t1 -和t2 - mri成像能力,从而准确诊断癌症。此外,合成的超小Mn3O4纳米颗粒对肿瘤细胞具有明显的铁致凋亡作用,并且具有良好的体内生物相容性,因此具有有效的癌症治疗应用前景。所研制的超小Mn3O4纳米颗粒具有gsh响应变量t1和t2 MRI成像效果和铁垂能力的双重功能,在临床应用中具有良好的肿瘤治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mass production of ultrasmall Mn3O4 nanoparticles for glutathione responsive off-on T1/T2 switching magnetic resonance imaging and tumor theranostics

Mass production of ultrasmall Mn3O4 nanoparticles for glutathione responsive off-on T1/T2 switching magnetic resonance imaging and tumor theranostics

Individual theranostics with an integrated multifunction holds considerable promise for clinical application compared with multicomponent regimes. Mn3O4 nanoparticles with an ultrasmall size (4 nm) and mass production capability were developed with dual function of integrated tumor magnetic resonance imaging (MRI) and therapy. The high valence state of Mn3O4 nanocrystals enables a sensitive reaction with the glutathione (GSH) molecule and favorable decomposition ability, which further induces a unique, favorable, variable T1 turn-off and T2 turn-on MRI property. In addition, ultrasmall Mn3O4 nanoparticles reacted with high-level GSH in the tumor microenvironment induces responsive and enhanced variable T1- and T2-MRI imaging capability for accurate cancer diagnosis. Moreover, the synthesized ultrasmall Mn3O4 nanoparticles exhibit considerable ferroptosis effect towards tumor cells and excellent in vivo biocompatibility, thus indicating promising effective cancer treatment application. The developed ultrasmall Mn3O4 nanoparticles with integrated dual functions of GSH-responsive variable T1 and T2 MRI imaging effects and ferroptosis capability show promising potential as a candidate for tumor theranostics in clinical applications.

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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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