天然产物对双酚a调控的mirna和靶点的保护作用

IF 9.7 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-02-01 DOI:10.1016/j.envint.2025.109299

Ya-Ting Chuang , Ching-Yu Yen , Wangta Liu , Tsu-Ming Chien , Fang-Rong Chang , Yi-Hong Tsai , Jen-Yang Tang , Hsueh-Wei Chang

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引用次数: 0

摘要

双酚A （BPA）是一种普遍存在的具有内分泌干扰功能的环境污染物。确定保护药物和探索对抗BPA的机制在医疗保健中至关重要。具有抗氧化特性的天然产物被认为能够防止双酚a毒性。尽管bpa调节的靶点和mirna已经被单独报道，但它们与天然产物的联系很少被组织起来。在蛋白质-蛋白质相互作用数据库（STRING）的帮助下，单个bpa调节靶点之间的关系相互关联，以提供一个系统的视图。本文对bpa下调和上调的靶点进行了分类，并创新性地利用生物信息学数据库（STRING）分析了它们之间的相互作用网络。bpa调节的mirna也被检索并巧妙地连接到bpa调节的靶标上。此外，对抗bpa的天然产物之间的新连接被整合到bpa调节的mirna和靶标中。所有这些与靶标相关的天然产物和/或mirna都被纳入STRING网络，提供了系统的关系。总体而言，创新性地构建了bpa调控的靶点- mirna保护天然产物轴，为探索天然产物的综合bpa对抗作用和机制提供了一个直观的方向

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The protection of bisphenol A-modulated miRNAs and targets by natural products

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The protection of bisphenol A-modulated miRNAs and targets by natural products

Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties are considered to be able to protect against BPA toxicity. Although BPA-modulated targets and miRNAs have been individually reported, their connections to natural products were rarely organized. With the help of a protein–protein interaction database (STRING), the relationship between individual BPA-modulated targets was interconnected to provide a systemic view. In this review, BPA-downregulated and -upregulated targets are classified, and their interactive network was innovatively analyzed using the bioinformatic database (STRING). BPA-modulated miRNAs were also retrieved and ingeniously connected to BPA-modulated targets. Moreover, a novel connection between BPA-countering natural products was integrated into BPA-modulated miRNAs and targets. All these targets-associated natural products and/or miRNAs were incorporated into the STRING network, providing systemic relationships. Overall, the BPA-modulated target–miRNA-protecting natural product axis was innovatively constructed, providing a straightforward direction for exploring the integrated BPA-countering effects and mechanisms of natural products.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.