Anne Lise Maucotel, Deborah M Crepin, Allison Faure, Florent Valour, Frédéric Laurent, Jérôme Josse
{"title":"表皮葡萄球菌假体关节感染的发病机制：细菌在成骨细胞、滑膜细胞和内皮细胞中的粘附和内化。","authors":"Anne Lise Maucotel, Deborah M Crepin, Allison Faure, Florent Valour, Frédéric Laurent, Jérôme Josse","doi":"10.1099/jmm.0.001959","DOIUrl":null,"url":null,"abstract":"<p><p><i>Staphylococcus epidermidis</i> is frequently isolated during prosthetic joint infections (PJIs). Unlike <i>Staphylococcus aureus</i>, its internalization and persistence within cells are controversial. We aimed to determine whether internalization is involved in the pathophysiology of <i>S. epidermidis</i> PJIs. Adhesion and internalization of <i>S. epidermidis</i> PJI isolates have been studied using an <i>in vitro</i> model. Despite similar adhesion levels to the <i>S. aureus</i> SH1000 reference strain, <i>S. epidermidis</i> isolates had a low internalization in osteoblasts, synoviocytes and endothelial cells. Internalization of <i>S. epidermidis</i> is strain- and cell-type dependent. Our results do not support <i>S. epidermidis</i> internalization as a key factor in PJIs.</p>","PeriodicalId":94093,"journal":{"name":"Journal of medical microbiology","volume":"74 1","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pathogenesis of <i>Staphylococcus epidermidis</i> prosthetic joint infections: bacterial adhesion and internalization in osteoblasts, synoviocytes and endothelial cells.\",\"authors\":\"Anne Lise Maucotel, Deborah M Crepin, Allison Faure, Florent Valour, Frédéric Laurent, Jérôme Josse\",\"doi\":\"10.1099/jmm.0.001959\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Staphylococcus epidermidis</i> is frequently isolated during prosthetic joint infections (PJIs). Unlike <i>Staphylococcus aureus</i>, its internalization and persistence within cells are controversial. We aimed to determine whether internalization is involved in the pathophysiology of <i>S. epidermidis</i> PJIs. Adhesion and internalization of <i>S. epidermidis</i> PJI isolates have been studied using an <i>in vitro</i> model. Despite similar adhesion levels to the <i>S. aureus</i> SH1000 reference strain, <i>S. epidermidis</i> isolates had a low internalization in osteoblasts, synoviocytes and endothelial cells. Internalization of <i>S. epidermidis</i> is strain- and cell-type dependent. Our results do not support <i>S. epidermidis</i> internalization as a key factor in PJIs.</p>\",\"PeriodicalId\":94093,\"journal\":{\"name\":\"Journal of medical microbiology\",\"volume\":\"74 1\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of medical microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1099/jmm.0.001959\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of medical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1099/jmm.0.001959","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pathogenesis of Staphylococcus epidermidis prosthetic joint infections: bacterial adhesion and internalization in osteoblasts, synoviocytes and endothelial cells.
Staphylococcus epidermidis is frequently isolated during prosthetic joint infections (PJIs). Unlike Staphylococcus aureus, its internalization and persistence within cells are controversial. We aimed to determine whether internalization is involved in the pathophysiology of S. epidermidis PJIs. Adhesion and internalization of S. epidermidis PJI isolates have been studied using an in vitro model. Despite similar adhesion levels to the S. aureus SH1000 reference strain, S. epidermidis isolates had a low internalization in osteoblasts, synoviocytes and endothelial cells. Internalization of S. epidermidis is strain- and cell-type dependent. Our results do not support S. epidermidis internalization as a key factor in PJIs.
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