真菌次生代谢物多样性及其在医疗保健和环境中的新应用综述。

IF 2 4区 生物学 Q2 AGRONOMY
Mycobiology Pub Date : 2024-12-03 eCollection Date: 2024-01-01 DOI:10.1080/12298093.2024.2416736
Khushbu Wadhwa, Neha Kapoor, Hardeep Kaur, Eman A Abu-Seer, Mohd Tariq, Sazada Siddiqui, Virendra Kumar Yadav, Parwiz Niazi, Pankaj Kumar, Saad Alghamdi
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引用次数: 0

摘要

真菌及其天然产物,如次生代谢物,在过去十年中由于其在医疗保健,环境清理和生物技术基础产业中的应用越来越多,已经获得了巨大的需求。真菌在其生长的不同阶段产生这些次生代谢物(SMs),分为萜类、生物碱、聚酮类和非核糖体肽。这些SMs表现出显著的生物活性,有助于新药,生物农药和环境生物修复剂的配方。如今,这些真菌衍生的SMs被广泛应用于食品和饮料、发酵、防腐剂、蛋白质来源和乳制品行业。在医疗保健领域,它被用作抗菌、抗癌、抗炎和免疫抑制药物。使用现代生物技术工具可以增加对这些SMs和大规模生产的需求。本文全面分析了真菌SMs的多样性及其在医疗保健、农业、环境可持续性和营养保健方面的新兴应用。本文综述了近年来在基因工程、代谢途径调控和合成生物学等方面的研究进展,以期提高该类植物的产量和产量。SMs大规模生产的发酵技术、生物加工和共培养方法的进展。研究人员进一步强调了组学技术在理解SMs的调控和生物合成方面的重要性,这为药物发现和可持续农业中的新应用提供了理解。最后,作者讨论了遗传操作和生物技术创新的潜力,以进一步开发真菌SMs的商业和环境效益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment.

Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to their increasing applications in healthcare, environmental cleanup, and biotechnology-based industries. The fungi produce these secondary metabolites (SMs) during the different phases of their growth, which are categorized into terpenoids, alkaloids, polyketides, and non-ribosomal peptides. These SMs exhibit significant biological activity, which contributes to the formulation of novel pharmaceuticals, biopesticides, and environmental bioremediation agents. Nowadays, these fungal-derived SMs are widely used in food and beverages, for fermentation, preservatives, protein sources, and in dairy industries. In healthcare, it is being used as an antimicrobial, anticancer, anti-inflammatory, and immunosuppressive drug. The usage of modern tools of biotechnology can achieve an increase in demand for these SMs and large-scale production. The present review comprehensively analyses the diversity of fungal SMs along with their emerging applications in healthcare, agriculture, environmental sustainability, and nutraceuticals. Here, the authors have reviewed the recent advancements in genetic engineering, metabolic pathway manipulation, and synthetic biology to improve the production and yield of these SMs. Advancement in fermentation techniques, bioprocessing, and co-cultivation approaches for large-scale production of SMs. Investigators further highlighted the importance of omics technologies in understanding the regulation and biosynthesis of SMs, which offers an understanding of novel applications in drug discovery and sustainable agriculture. Finally, the authors have addressed the potential for genetic manipulation and biotechnological innovations for further exploitation of fungal SMs for commercial and environmental benefits.

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来源期刊
Mycobiology
Mycobiology AGRONOMYMYCOLOGY-MYCOLOGY
CiteScore
3.90
自引率
5.30%
发文量
41
审稿时长
22 weeks
期刊介绍: Mycobiology is an international journal devoted to the publication of fundamental and applied investigations on all aspects of mycology and their traditional allies. It is published quarterly and is the official publication of the Korean Society of Mycology. Mycobiology publishes reports of basic research on fungi and fungus-like organisms, including yeasts, filamentous fungi, lichen fungi, oomycetes, moulds, and mushroom. Topics also include molecular and cellular biology, biochemistry, metabolism, developmental biology, environmental mycology, evolution, ecology, taxonomy and systematics, genetics/genomics, fungal pathogen and disease control, physiology, and industrial biotechnology using fungi.
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