Peter Jacobsson, Tove Granqvist, Christopher J Hopwood, Robert F Krueger, Bo Söderpalm, Thomas Nilsson
{"title":"人格功能障碍和适应不良人格特征如何预测ADHD药物治疗过早停止的时间？","authors":"Peter Jacobsson, Tove Granqvist, Christopher J Hopwood, Robert F Krueger, Bo Söderpalm, Thomas Nilsson","doi":"10.1177/10870547241309524","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Non-adherence to medication is common in the adult ADHD clinical group. The goal of this pre-registered study was to examine whether the DSM-5 Alternative Model of Personality Disorder (AMPD), generality personality dysfunction (LPFS-BF 2.0) or maladaptive personality traits (PID-5), can predict time to premature discontinuation of pharmacological treatment beyond other known factors.</p><p><strong>Methods: </strong>A sample of 284 adult patients with ADHD (60.6% female; <i>M</i><sub>age</sub> = 32.31 years) were investigated for medication adherence from 2018 to 2023, using time-to-event analytic methods.</p><p><strong>Results: </strong>Of the sample, 54 were found to have discontinued treatment prematurely without consulting their physician. Interestingly this group was prescribed considerably lower doses before discontinuation than adhering patients. General personality dysfunction and maladaptive antagonistic personality traits are implicated in varying degrees, with the specific maladaptive personality facets <i>Intimacy Avoidance</i> and <i>Deceitfulness</i> (PID-5) significantly predicting time to premature discontinuation of ADHD medication beyond other known reasons for non-adherence.</p><p><strong>Conclusions: </strong>The broader implication is that the emerging personality pathology models hold promise to predict non-adherence in the adult ADHD population.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"351-362"},"PeriodicalIF":2.7000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800730/pdf/","citationCount":"0","resultStr":"{\"title\":\"How Do Personality Dysfunction and Maladaptive Personality Traits Predict Time to Premature Discontinuation of Pharmacological Treatment of ADHD?\",\"authors\":\"Peter Jacobsson, Tove Granqvist, Christopher J Hopwood, Robert F Krueger, Bo Söderpalm, Thomas Nilsson\",\"doi\":\"10.1177/10870547241309524\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Non-adherence to medication is common in the adult ADHD clinical group. The goal of this pre-registered study was to examine whether the DSM-5 Alternative Model of Personality Disorder (AMPD), generality personality dysfunction (LPFS-BF 2.0) or maladaptive personality traits (PID-5), can predict time to premature discontinuation of pharmacological treatment beyond other known factors.</p><p><strong>Methods: </strong>A sample of 284 adult patients with ADHD (60.6% female; <i>M</i><sub>age</sub> = 32.31 years) were investigated for medication adherence from 2018 to 2023, using time-to-event analytic methods.</p><p><strong>Results: </strong>Of the sample, 54 were found to have discontinued treatment prematurely without consulting their physician. Interestingly this group was prescribed considerably lower doses before discontinuation than adhering patients. General personality dysfunction and maladaptive antagonistic personality traits are implicated in varying degrees, with the specific maladaptive personality facets <i>Intimacy Avoidance</i> and <i>Deceitfulness</i> (PID-5) significantly predicting time to premature discontinuation of ADHD medication beyond other known reasons for non-adherence.</p><p><strong>Conclusions: </strong>The broader implication is that the emerging personality pathology models hold promise to predict non-adherence in the adult ADHD population.</p>\",\"PeriodicalId\":15237,\"journal\":{\"name\":\"Journal of Attention Disorders\",\"volume\":\" \",\"pages\":\"351-362\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800730/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Attention Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10870547241309524\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Attention Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10870547241309524","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
How Do Personality Dysfunction and Maladaptive Personality Traits Predict Time to Premature Discontinuation of Pharmacological Treatment of ADHD?
Objectives: Non-adherence to medication is common in the adult ADHD clinical group. The goal of this pre-registered study was to examine whether the DSM-5 Alternative Model of Personality Disorder (AMPD), generality personality dysfunction (LPFS-BF 2.0) or maladaptive personality traits (PID-5), can predict time to premature discontinuation of pharmacological treatment beyond other known factors.
Methods: A sample of 284 adult patients with ADHD (60.6% female; Mage = 32.31 years) were investigated for medication adherence from 2018 to 2023, using time-to-event analytic methods.
Results: Of the sample, 54 were found to have discontinued treatment prematurely without consulting their physician. Interestingly this group was prescribed considerably lower doses before discontinuation than adhering patients. General personality dysfunction and maladaptive antagonistic personality traits are implicated in varying degrees, with the specific maladaptive personality facets Intimacy Avoidance and Deceitfulness (PID-5) significantly predicting time to premature discontinuation of ADHD medication beyond other known reasons for non-adherence.
Conclusions: The broader implication is that the emerging personality pathology models hold promise to predict non-adherence in the adult ADHD population.
期刊介绍：
Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.
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