高致病性肺炎克雷伯菌家族传播所致的无并发症咽炎。

IF 3.7 3区医学 Q2 INFECTIOUS DISEASES

European Journal of Clinical Microbiology & Infectious Diseases Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI:10.1007/s10096-025-05043-6

Hannah K Gray, Sanchi Malhotra, Shekina Gonzalez-Ferrer, Gregory D Whitehill, Alisa C Chalmers, Shangxin Yang

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引用次数: 0

摘要

我们描述了两个家庭中由高致病性肺炎克雷伯菌（hvKp）引起的无并发症咽炎病例，最初发生在免疫功能正常的青少年中，随后可能在家庭中传播，导致患者父母出现类似症状。基因组分析证实两例hvKp基因相同，分型为K2-ST3252。鼻咽运输和呼吸道分泌物/飞沫可能在hvKp的传播中发挥重要作用，但尚未得到充分认识。在上呼吸道培养中加强hvKp的常规筛查，然后进行基因分型，为早期诊断提供了有效途径。

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Uncomplicated pharyngitis due to family transmission of hypervirulent Klebsiella pneumoniae.

We describe two cases of uncomplicated pharyngitis caused by hypervirulent Klebsiella pneumoniae (hvKp) in a family, initially in an immunocompetent adolescent, followed by possible household spread resulting in similar presentations in the patient's parent. Genomic analysis confirmed hvKp from the two cases were genetically identical and typed as K2-ST3252. Nasopharyngeal carriage and respiratory secretion/droplet may play an important yet underrecognized role in the transmission of hvKp. Enhancing routine screening for hvKp in the upper respiratory culture, followed by genotyping provides an effective pathway for early diagnosis.

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来源期刊

European Journal of Clinical Microbiology & Infectious Diseases 医学-传染病学

CiteScore

10.40

自引率

2.20%

发文量

138

审稿时长

1 months

期刊介绍： EJCMID is an interdisciplinary journal devoted to the publication of communications on infectious diseases of bacterial, viral and parasitic origin.