利用化学蛋白质组学工具分析宿主-病原体相互作用中的S-itaconation。

IF 5.9 2区 生物学 Q1 MICROBIOLOGY
Zihua Liu , Chu Wang
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引用次数: 0

摘要

宿主和病原体之间战斗的分子本质在于蛋白质-蛋白质或蛋白质-代谢物的相互作用。衣康酸酯是一种上调最多的免疫代谢物,通过非共价结合或共价修饰在宿主体内调节免疫反应。本文简要介绍衣康酸的生理和病理作用的最新发现,以及化学蛋白质组学技术在探索衣康酸在宿主-病原体相互作用界面上对半胱氨酸的修饰(S-itaconation)方面的应用。并提出了未来展望的主要挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dissecting S-itaconation at host–pathogen interactions with chemical proteomics tools
The molecular essence of the battle between host and pathogens lies in the protein–protein or protein–metabolite interactions. Itaconate is one of the most upregulated immunometabolites, regulating immune responses through either noncovalent binding or covalent modification in the host. We herein briefly review recent progresses in the discoveries of physiological and pathological roles of itaconate and applications of chemical proteomic technologies in exploring itaconate modifications on cysteines (S-itaconation) at the interface of host–pathogen interactions. Key challenges are also proposed as future outlook.
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来源期刊
Current opinion in microbiology
Current opinion in microbiology 生物-微生物学
CiteScore
10.00
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes
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