印度北阿坎德邦姜花根茎油树脂的生物活性及化学成分分析。

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Combinatorial chemistry & high throughput screening Pub Date : 2025-01-07 DOI:10.2174/0113862073327439241119113953

Sushila Arya, Ravendra Kumar, Om Prakash, Mamta Latwal, Ganesh Pandey, Satya Kumar, R M Srivastava, Suraj N Mali

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引用次数: 0

摘要

简介：姜黄（Hedychium coronarium J. König），来自姜科，是一种根状草本植物，因其具有退热、抗风湿和驱虫药的特性而被用于印度草药。方法：研究了在北阿坎德邦潘特纳格尔（Pantnagar）、巴格什瓦尔（Bageshwar）、奈尼塔尔（Nainital）和皮托拉加尔（Pithoragarh） 4个地点采集的姜花油树脂的化学多样性和生物活性。GC-MS分析鉴定出主要成分为正十六酸（8.3-9.8%）、光柠檬醛B（4.8- 27.6%）、(Z)-9-二十烯酸（0.7-6.5%）、α-蒎烯（2.5-3.5%）和反式13-十八烯酸（7.5%）。热图聚类、维恩图和主成分分析揭示了成分的变化。结果：该油树脂对黑线蛾、斜纹夜蛾、斜纹夜蛾等具有较强的杀线虫、杀虫、除草和抗真菌活性。镰刀菌，镰刀菌和弯孢菌。结论：在环境因素的驱动下，姜花油树脂的化学成分变化具有防治病虫害和病原菌的潜力。

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Therapeutic Bioactivities and Chemical Composition Analysis of Rhizome Oleoresin of Hedychium coronarium Collected from Uttarakhand, India.

Introduction: Hedychium coronarium J. König, from the Zingiberaceae family, is a rhizomatous herb used in Ayurvedic medicine for its febrifuge, anti-rheumatic, and anthelmintic properties.

Method: This study characterizes the chemical diversity and biological activities of H. coronarium oleoresins collected from four locations in Uttarakhand: Pantnagar (HCPNOR), Bageshwar (HCBOR), Nainital (HCNOR) and Pithoragarh (HCPOR). GC-MS analysis identified key constituents, including n-Hexadecanoic acid (8.3-9.8%), photocitral B (4.8- 27.6%), (Z)-9- eicosenoic acid (0.7-6.5%), α-pinene (2.5-3.5%) and trans-13-octadecenoic acid (7.5%). Heat map clustering, Venn diagrams, and PCA revealed compositional variations.

Result: The oleoresins showed potent nematicidal, insecticidal, herbicidal, and antifungal activities against Meloidogyne incognita, Spodoptera litura, Raphanus raphanistrum subsp. sativus, Fusarium oxysporum, and Curvularia lunata.

Conclusion: These findings highlight the potential of H. coronarium oleoresins for pest and pathogen management, with chemical variation driven by environmental factors.

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来源期刊

Combinatorial chemistry & high throughput screening 化学-生化研究方法

CiteScore

3.10

自引率

5.60%

发文量

327

审稿时长

7.5 months

期刊介绍： Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.