将改性的两亲性秋莲子淀粉整合到富含姜黄素的皮克林乳剂中，以提高生物利用度、热稳定性和疏水生物活性化合物的保留。

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2024-12-30 DOI:10.1016/j.carbpol.2024.123199

Zafarullah Muhammad , Rabia Ramzan , Abdullah , Hafiz Muhammad Khalid Abbas , Wu Sun , Guoqiang Zhang

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引用次数: 0

摘要

该研究涉及对从未充分利用的荸荠品种（CWC）中分离的一种非常规淀粉进行改性，并将其整合到稳定的富含姜黄素的皮pickering乳剂中，该乳剂具有增强的生物利用度、热稳定性和包膜姜黄素的保留性。采用高效半干燥酯化法制备了3、6、9% （w/v）辛烯基丁二酸酐（OSA）改性两亲性淀粉，并通过取代度（DS）、接触角、粒径、扫描电镜（SEM）、x射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和体外消化率进行了表征。此外，以3%、6%和9%浓度的CWCS-OSA配制Pickering乳剂，作为姜黄素的载体，提高其水溶性和储存稳定性。研究了皮克林乳剂的包封率、姜黄素保留率、乳化性能、微形貌、温度稳定性和生物可及性。结果表明，当OSA浓度为3% ~ 9%时，CWCS-OSA的取代度（DS）为0.017 ~ 0.031，接触角扩展为68.36 ~ 85.45。CWCS-9%OSA的包封率最高，为89.4%，在10 d的贮存期内乳化指数保持在80%以上。CWCS-9%OSA稳定的Pickering乳剂中姜黄素的生物可达性（41.26±1.34%）显著高于散装油体系（19.53±1.62%）。本研究强调了利用未充分利用的CWCS品种（Eleocharis tuberosa）对两亲性淀粉进行化学改性的潜力，通过提高不稳定疏水多酚化合物在食品和制药中的生物利用度，生产稳定的皮pickering乳液凝胶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Integrating the modified amphiphilic Eleocharis tuberosa starch to stabilize curcuminoid-enriched Pickering emulsions for enhanced bioavailability, thermal stability, and retention of the hydrophobic bioactive compound

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The study involves the modification of a non-conventional starch isolated from the under-utilized variety of Chinese water chestnut (CWC (Eleocharis tuberosa) and integrating it to fabricate stabilized and curcumin-enriched Pickering emulsions with enhanced bioavailability, thermal stability, and retention of encapsulated curcumin. A time-efficient, semi-dried esterification method was used to prepare modified amphiphilic starches using 3, 6, or 9 % (w/v) octenyl succinic anhydride (OSA) and characterized through degree of substitution (DS), contact angle, particle size, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and in-vitro digestibility. Moreover, Pickering emulsions were formulated using CWCS-OSA at 3 %, 6 %, or 9 % concentrations to serve as a carrier for curcumin to improve its water solubility and storage stability. The research investigated Pickering emulsions' encapsulation efficiency, curcumin retention, emulsifying properties, micromorphology, temperature stability, and bioaccessibility. Results showed that CWCS-OSA, with an OSA concentration between 3 % and 9 %, exhibited a degree of substitution (DS) ranging from 0.017 to 0.031 and an expansion in contact angle from 68.36^o to 85.45^o. CWCS-9%OSA showed the highest encapsulation efficiency at 89.4 % and maintained an emulsification index above 80 % during a 10-day storage period. A significantly higher bio-accessibility (41.26 ± 1.34 %) of curcumin in Pickering emulsions stabilized with CWCS-9%OSA than in the bulk oil system (19.53 ± 1.62 %). This study highlights the potential of chemically modified amphiphilic starch from an underutilized variety of CWCS (Eleocharis tuberosa) to produce the stabilized Pickering emulsion gels as a stable and effective carrier for unstable hydrophobic polyphenolic compounds by enhancing their bioavailability in the foods and pharmaceutics.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.