与商用晶体羟基磷灰石骨矿物竞争的单相硅岭土(α-和β-Na2Ca4(PO4)2SiO4)生物活性玻璃材料的制备。

IF 5.5 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS
Vijayakumari Sugumaran, Annamalai Kamalakkannan, Elakkiya Krishnamoorthy, Gosala Radha, Balakumar Subramanian
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引用次数: 0

摘要

羟基磷灰石(Hydroxyapatite, HAP)是医学界公认的生物活性材料,具有良好的生物相容性和机械稳定性,但缺乏快速的生物活性。羟基磷灰石离子的限制性释放促使人们寻找一种更快的生物活性材料,这种材料可以复制HAP的其他特性。本研究制备了一种新的溶胶-凝胶介导的潜在生物活性玻璃材料,它可以模拟HAP的结构,但生物活性可以超过HAP的性能。Lefebvre等人认为分子式为Na2Ca4(PO4)2SiO4的硅长石相与羟基磷灰石是同构的;然而,支持这一假设的数据很少。本研究成功地开发了类似羟基磷灰石结构的诱导磷灰石快速生长的生物活性玻璃颗粒。同时,首次揭示了α-和β-Na2Ca4(PO4)2SiO4两种硅长石的存在和演化,并对其性质进行了探索。通过观察900℃热处理得到α-Na2Ca4(PO4)2SiO4 (Sili 900), 1000℃热处理得到β-Na2Ca4(PO4)2SiO4 (Sili 1000)的结果,揭示了煅烧温度对生物材料相形成的影响。本研究发现羟基磷灰石与β-Na2Ca4(PO4)2SiO4是同构的,而与α-Na2Ca4(PO4)2SiO4不是同构的。拉曼光谱分析证明了Sili 1000和c-HAP的结构相似性,其相对光谱具有磷酸带,而Sili 900与Sili 1000和c-HAP不相关。利用NIH 3T3成纤维细胞进行的体外MTT实验和体内伤口愈合研究证实,与c-HAP相比,Sili 900和Sili 1000具有更高的生物活性和相容性,这得益于二氧化硅基质的存在和半结晶性。pH分析表明,硅里900和硅里1000的离子浸出速度较快,硅里1000与流体的反应性较快。这种离子的快速爆发增强了Sili 1000生物活性物质的凝血能力,可以作为一种良好的布洛芬药物载体,是羟基磷灰石的潜在挑战者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulating Single Phasic Silicorhenanite (α- and β-Na2Ca4(PO4)2SiO4) Bioactive Glass Materials Competing with Commercial Crystalline Hydroxyapatite Bone Mineral for Biomedical Applications.

Hydroxyapatite (HAP) is a well-known medically renowned bioactive material known for its excellent biocompatibility and mechanical stability, but it lacks fast bioactivity. The restricted release of ions from hydroxyapatite encourages the search for a faster bioactive material that could replicate other properties of HAP. A new sol-gel-mediated potentially bioactive glass material that could mimic the structure of HAP but can surpass the performance of HAP bioactively has been formulated in this study. Lefebvre et al. suggested that the silicorhenanite phase with the formula Na2Ca4(PO4)2SiO4 is isostructural to hydroxyapatite; however, data in support of this hypothesis are scant. This study succeeds in developing fast apatite-growth-inducing bioactive glass particles similar to the structure of hydroxyapatite. Also, for the first time, the existence and evolution of two forms of silicorhenanite (α- and β-Na2Ca4(PO4)2SiO4) have been unraveled, and their properties have been explored. The effect of calcination temperature on the phase formation of the biomaterial is notified by looking into the result that heat treatment to 900 °C resulted in α-Na2Ca4(PO4)2SiO4 (Sili 900) and 1000 °C yielded β-Na2Ca4(PO4)2SiO4 (Sili 1000). This study conveys a new finding that the hydroxyapatite is isostructural to β-Na2Ca4(PO4)2SiO4 but not to α-Na2Ca4(PO4)2SiO4. Raman spectroscopic analysis proved this structural similarity of Sili 1000 and c-HAP, with relative spectra possessing phosphate bands and the irrelevance of Sili 900 to Sili 1000 and c-HAP. The in vitro MTT assay using NIH 3T3 fibroblasts and in vivo wound healing study confirm the enhanced bioactivity and compatibility of Sili 900 and Sili 1000 compared to c-HAP, favored by the presence of a silica matrix and semicrystallinity. pH analysis proved the rapid ionic leaching out from Sili 900 and Sili 1000 and the faster reactivity of Sili 1000 with the fluid. This rapid burst of ions enhances the clotting ability of the Sili 1000 bioactive material and can be a good ibuprofen drug carrier, which is a potential challenger to hydroxyapatite.

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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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