负载季铵化壳聚糖修饰金属镓-有机骨架的定向冷冻凝胶捕获和消灭耐药细菌用于感染骨缺损的引导再生

IF 26.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yihao Liu, Kai Yuan, Yixuan Lin, Yiqi Yang, Weiqing Kong, Jing Shan, Haoyi Niu, Weize Kong, Fupeng Li, Xiaokun Yue, Yun Du, Yakun Liang, Haishuang Chang, Zhifeng Yu, Jinwu Wang, Guangzheng Yang, Lingyan Cao, Kai Huang, Shengbing Yang, Tingting Tang
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引用次数: 0

摘要

抗菌药物耐药性和骨再生受损是治疗感染性骨缺损的巨大挑战。它的复发性和耐药性、高发病率、长期住院和高昂的医疗费用促使科学界努力开发新的治疗方法来改善这种情况。考虑到复杂的微环境和耐药菌介导的持续机制,开发具有增强骨整合和持续有效的感染清除效果的种植体至关重要。本文设计了一种带正电荷的季铵化壳聚糖(QCS)涂层镓基金属有机框架(GaMOF),以捕获耐抗生素细菌(耐甲氧西林金黄色葡萄球菌,MRSA)作为“捕集器”,并通过干扰三羧酸(TCA)循环使甲氧西林(Me)恢复活力。然后,采用定向冷冻铸造的方法制备了装载Me和QCSGaMOF的径向定向多孔低温凝胶。定向多孔结构通过引导成骨细胞向内生长而增强骨整合作用。体外和体内实验证明了制备的Me/QCSGa-MOF@Cryogel在对抗耐药细菌和引导感染骨缺损骨再生方面的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal–Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects

Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected bone defects. Its recurrent and resistant nature, high incidence rate, long-term hospitalization, and high medical costs have driven the efforts of the scientific community to develop new therapies to improve the situation. Considering the complex microenvironment and persistent mechanisms mediated by resistant bacteria, it is crucial to develop an implant with enhanced osseointegration and sustained and effective infection clearance effects. Here, a positively charged quaternized chitosan (QCS) coated gallium-based metal–organic framework (GaMOF) is designed, to capture the antibiotic-resistant bacteria (Methicillin-resistant Staphylococcus aureus, MRSA) as a “captor”, and rejuvenate Methicillin (Me) via disturbing the tricarboxylic acid (TCA) cycle. Then, a radially oriented porous cryogel loaded with the Me and QCSGaMOF is fabricated by the directional freeze-casting method. The oriented porous structure has an enhanced osseointegration effect by guiding the ingrowth of osteogenic cells. In vitro and in vivo experiments prove the advantages of as-prepared Me/QCSGa-MOF@Cryogel in combating resistant bacteria and guiding bone regeneration in infected bone defects.

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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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