理查德·卡什:公共卫生医生,他为霍乱患者提供的盐和糖溶液估计挽救了7000万人的生命

The BMJ Pub Date : 2025-01-23 DOI:10.1136/bmj.r120
Joanne Silberner
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引用次数: 0

摘要

1967年,新获得资格的医生理查德·卡什被派往东巴基斯坦(现在的孟加拉国),应对横扫该地区的众多霍乱疫情之一。当时的治疗方法是静脉注射,以补充流失的液体,但在一个资金和训练有素的人员都无法达到所需规模的国家,这种资源密集型的治疗方法是不合适的。然而,一种简单、廉价、易于实施的治疗方法确实存在:口服补液疗法(ORT),只是在干净的水中加入盐和糖。这在实验室研究中已经被证明是有效的,但卡什和他在美国国立卫生研究院的同事戴维·纳林(David Nalin)决定在更大的范围内进行测试。他们面临着同事们的反对,他们不确定病人是否能够吞下这种液体,也不确定这种治疗是否有效——但他们对ORT的多次临床试验证明,怀疑论者是错误的卡什继续与……
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Richard Cash: public health doctor whose salt and sugar solution for cholera patients is estimated to have saved 70 million lives
BRAC In 1967 newly qualified doctor Richard Cash was sent to East Pakistan (now Bangladesh) to respond to one of the many cholera epidemics that swept through the region. The treatment at the time was intravenous therapy to replace lost fluids, but such a resource intensive process was inappropriate in a country where funding and trained personnel were not available at anywhere near the scale needed. A simple, inexpensive, and easy to administer treatment did, however, exist: oral rehydration therapy (ORT), just salt and sugar in clean water. This had already been shown to be effective in laboratory studies but Cash and David Nalin, his colleague at the US National Institutes for Health, decided to test it on a much larger scale. They faced objections from colleagues who weren’t sure patients would be able to swallow the fluid or that the treatment would work—but their multiple clinical trials of ORT proved the doubters wrong.1 Cash went on to work closely with the …
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