揭示GLP-1受体激动剂药物的广泛健康益处和风险

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2025-01-23 DOI:10.1038/s41591-024-03476-8

引用次数: 0

摘要

本研究系统分析了200万人使用胰高血糖素样肽-1受体激动剂（GLP-1RAs）或其他降糖药物的175例健康结果。GLP-1RAs降低了神经认知、物质使用、心血管和呼吸系统疾病的风险，但增加了胃肠道问题、低血压和胰腺炎的风险。该研究为临床实践和未来的研究提供了重要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Unlocking the broad health benefits and risks of GLP-1 receptor agonist drugs

查看原文本刊更多论文

Unlocking the broad health benefits and risks of GLP-1 receptor agonist drugs

This study systematically analyzed 175 health outcomes in 2 million people using glucagon-like peptide-1 receptor agonists (GLP-1RAs) or other antihyperglycemics. GLP-1RAs reduce risks of neurocognitive, substance use, cardiovascular and respiratory disorders, but increase risks of gastrointestinal issues, hypotension and pancreatitis. The study provides important insights for clinical practice and future research.

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

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