肾脏α-突触核蛋白沉积可能与帕金森病有关

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-01-23 DOI:10.1038/s41593-024-01867-1

引用次数: 0

摘要

在帕金森病（PD）的发病过程中，α-突触核蛋白病理可能起源于外周器官并扩散到中枢神经系统。使用人体组织样本和多种方法在小鼠肾衰竭模型中，我们证明肾脏是PD中病理性α-突触核蛋白的起源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

α-Synuclein deposition in the kidney may contribute to Parkinson’s disease

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α-Synuclein deposition in the kidney may contribute to Parkinson’s disease

During the pathogenesis of Parkinson’s disease (PD), α-synuclein pathology may originate in peripheral organs and spread to the CNS. Using human tissue samples and multiple approaches in mouse models of renal failure, we demonstrated that the kidney serves as an origin of pathological α-synuclein in PD.

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.