人类胸腺血管组织移植的新方法：一例报告。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-01-01 DOI:10.1016/j.transproceed.2024.11.036

Luis F. Tintinago-Londoño , Francisco J. Jaramillo-Echeverry , Tania M. Guzmán , Juan C. Bravo-Ocaña , Nhora M. Silva-Pérez , José Abella-Calle

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引用次数: 0

摘要

背景：血管胸腺移植已在动物模型中进行了探索，但尚未在人体中进行试验。目前治疗先天性胸腺不全的方法包括异体胸腺组织的无血管移植，这可能会延迟免疫恢复。在动物研究的基础上，我们提出在人体模型中胸腺组织血运重建。本病例详细报道了一位晚期癌症老年妇女的新生儿胸腺组织血运重建，评估了3周内的血运重建效果、排斥风险和手术安全性。病例报告：在心脏矫正手术中获得的新生儿胸腺组织移植物被植入一名85岁妇女的左桡骨前臂。移植3周后，一条胸腺静脉与头静脉吻合，一条胸腺动脉与桡动脉吻合。未采用免疫抑制或HLA配型。每周多普勒超声和移植后组织病理学监测血流和移植物状态。进行血液学、生化、放射学评价及日常临床随访。结论：本初步研究证明了应用显微外科技术重建成人新生儿胸腺血运的可行性。

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Novel Approach to Vascular Thymic Tissue Transplantation in Humans: A Case Report

Background

Vascular thymus transplantation has been explored in animal models but remains untested in humans. Current approaches to congenital athymia involve avascular transplantation of allogeneic thymic tissue, which may delay immune recovery. Building on animal studies, we propose revascularization of thymic tissue in a human model. This case report details about the revascularization of neonatal thymic tissue in an elderly woman with terminal cancer, evaluating revascularization efficacy, rejection risks, and procedural safety over a 3-week period.

Case report

A thymic tissue graft obtained from a neonate during corrective heart surgery was implanted into the left radial forearm of an 85-year-old woman. The graft was evaluated for 3 weeks, with one thymic vein anastomosed to the cephalic vein and one thymic artery to the radial artery. No immunosuppression or HLA matching was employed. Weekly Doppler ultrasound and postexplantation histopathology monitored blood flow and graft status. Hematologic, biochemical, radiological evaluations, and daily clinical follow-up were conducted.

Conclusion

This preliminary research demonstrates the feasibility of revascularizing a neonatal thymus in an adult using microsurgical techniques.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.