光动力疗法对阴道上皮内瘤变1级的影响：一项回顾性队列研究。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2025.104486

Yao Yang , Dan Cao , Yi Chen, Ying Xu, Zhenhong Xiong, Zhengrong Zhang, Dan Wu

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引用次数: 0

摘要

目的：评价光动力疗法（PDT）治疗高危（Hr）人乳头瘤病毒（HPV）相关阴道上皮内瘤变1级（VaIN1）的疗效。方法：回顾性分析2022年3月至2022年9月期间接受VaIN1治疗的25-65岁参与者，分为三组。PDT组和随访组在妊娠、HPV类型和涉及的象限方面按1:1匹配。PDT组与CO2激光组进行不匹配比较。随访时间分别为6、12、24个月。结果：配对后，PDT组6、12、24个月病变清除率和Hr-HPV清除率（89.5%、89.5%、92.1%、81.6%、84.2%、89.5%）显著高于随访组（31.6%、50.0%、63.2%、21.1%、26.3%、31.6%），P2激光组（68.7%、78.3%、85.5%，P>0.05）， 6、12个月Hr-HPV清除率（PDT组62.2%、77.8%，CO2激光组54.2%、61.4%，P>0.05）显著高于PDT组（P >0.05）。然而，在24个月时，PDT组的Hr-HPV清除率高于CO2激光组（86.7% vs 71.1%， P=0.047）。在PDT组中，没有任何病变进展。结论：与CO2激光相比，PDT导致更高的Hr-HPV清除率，并发症和疾病进展的风险较低。PDT是一种有效的无创治疗VaIN1的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study

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Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study

Objective

To evaluate the efficacy of photodynamic therapy (PDT) for vaginal intraepithelial neoplasia grade 1 (VaIN1) related to high-risk (Hr)-human papillomavirus (HPV).

Methods

Participants aged 25–65 years treated for VaIN1 between March 2022 and September 2022 were retrospectively analyzed into three groups. The PDT and follow-up groups were matched 1:1 for gravidity, HPV type, and quadrants involved. The PDT and CO₂ laser groups were compared without matching. Patients were followed up at 6, 12, and 24 months.

Results

After matched, the lesion and Hr-HPV clearance rates of the PDT group (89.5%, 89.5%, 92.1%, and 81.6%, 84.2%, 89.5%) were significantly higher than those of the follow-up group (31.6%, 50.0%, 63.2%, and 21.1%, 26.3%, 31.6%, P < 0.05) at 6, 12, and 24 months. But the lesion clearance rates did not differ significantly between the PDT (68.9%, 82.2%, and 91.1%) and CO₂ laser groups (68.7%, 78.3%, and 85.5%, P > 0.05) at 6, 12, and 24 months, and so did Hr-HPV clearance rates (PDT as 62.2% and 77.8%, and CO₂ laser 54.2% and 61.4%, respectively, P > 0.05) at 6 and 12 months. However, at 24 months, the Hr-HPV clearance rate was higher in the PDT group than in the CO₂ laser group (86.7% vs 71.1%, P = 0.047). In the PDT group, none of the lesions progressed.

Conclusions

Compared with CO₂ laser, PDT resulted in a higher Hr-HPV clearance, as well as a low risk of complications and disease progression. PDT is an effective and noninvasive treatment for VaIN1.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.