Evaluating AI Chatbot Responses to Postkidney Transplant Inquiries

This study evaluated the capability of three AI chatbots—ChatGPT 4.0, Claude 3.0, and Gemini Pro, as well as Google—in responding to common postkidney transplantation inquiries. We compiled a list of frequently asked postkidney transplant questions using Google and Bing. Response quality was rated on a 5-point Likert scale, while understandability and actionability were measured with the Patient Education Materials Assessment Tool (PEMAT). Readability was assessed using the Flesch Reading Ease and Flesch-Kincaid Grade Level metrics, with statistical analysis conducted via non-parametric tests, specifically the Kruskal-Wallis test, using SPSS. We gathered 127 questions, which were addressed by the chatbots and Google. The responses were of high quality (median Likert score: 4 [4,5]), good understandability (median PEMAT understandability score: 72.7% [62.5,77.8]), but poor actionability (median PEMAT operability score: 20% [0%-20%]). The readability was challenging (median Flesch Reading Ease score: 22.1 [8.7,34.8]), with a Flesch-Kincaid Grade Level akin to undergraduate-level text (median score: 14.7 [12.3,16.7]). Among the chatbots, Claude 3.0 provided the most reliable responses, though they required a higher reading level. ChatGPT 4.0 offered the most comprehensible responses. Moreover, Google did not outperform the chatbots in any of the scoring metrics.