哮喘患者镁耗尽评分与全因死亡率和心血管死亡率之间的关系：一项基于2005-2018年NHANES人群的研究

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-01-16 DOI:10.1016/j.jtemb.2025.127602

Lanxin Fan , Xueqing Gong , Hongling Jia

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引用次数: 0

摘要

背景：本研究旨在探讨镁耗尽评分（MDS）与哮喘患者全因死亡率和心血管死亡率之间的潜在关联，MDS是一种新的体内镁状态评估方法。方法：利用2005 - 2018年全国健康与营养调查（NHANES）的数据，将4757例哮喘患者纳入研究，根据MDS水平（MDS=0、MDS=1、MDS=2和MDS≥3）分为4组。采用Kaplan-Meier曲线分析不同MDS组之间的生存差异，并采用加权多变量Cox回归模型评估MDS与死亡率之间的关系。此外，采用限制性三次样条（RCS）回归模型探讨MDS与全因死亡率和心血管死亡率之间的非线性关系，并进行亚组分析以验证结果。结果：Kaplan-Meier曲线显示，MDS水平高组的全因死亡率和心血管死亡率均显著升高（P ）。结论：MDS水平高独立预测美国成人哮喘患者的死亡风险，尤其是心血管死亡率。因此，MDS可能成为一种具有成本效益和广泛应用的哮喘预后评估工具，为临床决策和患者管理提供重要参考。

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Relationship between the magnesium depletion score and all-cause and cardiovascular mortality among asthma patients: A Study based on the NHANES population from 2005–2018

Background

This study aimed to investigate the potential association between magnesium depletion score (MDS), a novel assessment of magnesium status in vivo, and all-cause and cardiovascular mortality in asthma patients.

Methods

Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 4757 asthmatics were included in the study and were categorized into four groups based on their MDS levels (MDS=0, MDS=1, MDS=2, and MDS≥3). Survival differences between the different MDS groups were analysed using Kaplan-Meier curves, and weighted multivariate Cox regression models assessed the relationship between MDS and mortality. In addition, non-linear relationships between MDS and all-cause and cardiovascular mortality were explored using restricted cubic spline (RCS) regression models, and subgroup analyses were performed to validate the results.

Results

Kaplan-Meier curves showed that both all-cause and cardiovascular mortality were significantly higher in the group with higher levels of MDS (P < 0.001). After controlling for all confounders, asthmatics in the higher MDS group faced a higher risk of death compared with the lower MDS group, as evidenced by a 3.29-fold increase in all-cause mortality (95 % CI: 2.05, 5.29) and a 4.68-fold increase in cardiovascular mortality (95 % CI: 1.77, 12.35). Fully adjusted Cox regression models further confirmed the significant positive association of high MDS with the risk of all-cause and cardiovascular mortality.RCS plots revealed a linear dose-response relationship between MDS and mortality. In the subgroup analyses, no interaction factors other than cardiovascular disease were found to significantly influence the relationship between MDS and mortality.

Conclusion

Higher levels of MDS independently predicted the risk of mortality, especially cardiovascular mortality, in US adults with asthma. Therefore, the MDS may become a cost-effective and widely applicable prognostic assessment tool for asthma, providing an important reference for clinical decision-making and patient management.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.