IMAGEN样本中外化特征和症状的脑结构相关性

Nathaniel L Phillips, Brinkley M Sharpe, Courtland S Hyatt, Max M Owens, Nathan T Carter, Donald R Lynam, Tobias Banaschewski, Arun L W Bokde, Gareth Barker, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Nathalie Holz, Christian Baeuchl, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Joshua D Miller
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引用次数: 0

摘要

支持与外化谱(EXT)相关的个体大脑结构存在的证据是稀疏和混杂的。迄今为止,通过只关注与ext相关的人格特征(例如,Hyatt et al., 2022)或与ext相关的疾病/症状(例如,newton et al., 2022),对大脑- ext关系的大样本研究主要发现无效或非常小的影响。在这项使用IMAGEN数据(N = 1370)的预登记研究中,我们研究了跨形态测量特异性水平的EXT因素的脑结构相关性,这些因素包括人格(例如,对抗)和精神病理结构(例如,行为障碍)。脑形态测量是根据综合测量(例如,总脑容量)、皮质下体积和Desikan图谱区域(N = 161个结构磁共振成像指标)进行的。我们通过对EXT相关措施的探索性因素分析来操作我们的综合人格-精神病理学EXT,该措施确定了两个维度-非物质使用和物质使用-以及一个总体EXT领域。结果与之前EXT的大样本神经科学研究一致:绝大多数关系为零,所有效应量都非常小(最大边际R²< 0.02)。预先登记的补充分析表明,所有发现的显著关系都是由参与者的总颅内容量和性别驱动的,在纳入这些协变量后变得不显著。最后,我们就临床神经科学研究中相关协变量和大样本的重要性提出建议。(PsycInfo Database Record (c) 2025 APA,版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural brain correlates of externalizing traits and symptoms in the IMAGEN sample.

The evidence supporting the presence of individual brain structure correlates of the externalizing spectrum (EXT) is sparse and mixed. To date, large-sample studies of brain-EXT relations have mainly found null to very small effects by focusing exclusively on either EXT-related personality traits (e.g., Hyatt et al., 2022) or EXT-related disorders/symptoms (e.g., Mewton et al., 2022). In this preregistered study using IMAGEN data (N = 1,370), we investigated the structural brain correlates of EXT factors that comprise both personality (e.g., antagonism) and psychopathology constructs (e.g., conduct disorder) across levels of morphometric specificity. Brain morphometry was operationalized in terms of omnibus measures (e.g., total brain volume), subcortical volume, and Desikan atlas regions (N = 161 structural magnetic resonance imaging metrics). We operationalized our integrated personality-psychopathology EXT through exploratory factor analyses of EXT-related measures, which identified two dimensions-nonsubstance use and substance use-and one overarching EXT domain. The results were consistent with previous large-sample neuroscientific investigations of EXT: The vast majority of relations were null, and all effect sizes were very small (largest marginal < .02). Preregistered supplementary analyses indicated that all significant relations found were driven by total intracranial volume and sex of the participant and became nonsignificant following the inclusion of these covariates. We conclude with suggestions regarding the importance of relevant covariates and large samples in clinical neuroscientific investigations. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

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