赖氨酸乳酸化在癌症中的现状和未来展望。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-01-20 DOI:10.1016/j.tcb.2024.12.015

Sijia Li, Lixia Dong, Kui Wang

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引用次数: 0

摘要

乳酸是一种糖酵解中间体，在肿瘤代谢和微环境重塑中起着至关重要的作用。最近，研究人员发现乳酸介导赖氨酸乳酸化，这是一种新的蛋白质翻译后修饰（PTM）。本文就赖氨酸乳酸化作用在癌症中的作用及其机制进行综述，并对靶向赖氨酸乳酸化作用在癌症治疗中的潜力进行探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current and future perspectives of lysine lactylation in cancer.

Lactate, a glycolytic intermediate, has a crucial role in cancer metabolism and microenvironment remodeling. Recently, researchers found that lactate mediates lysine lactylation, a novel protein post-translational modification (PTM). Here, we summarize the mechanism and role of lysine lactylation in cancer, and discuss the potential of targeting lysine lactylation in cancer therapy.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.