生殖系基因组编辑对人有影响还是对身份有影响,这有关系吗?

IF 1.7 2区 哲学 Q2 ETHICS
Bioethics Pub Date : 2025-01-17 DOI:10.1111/bioe.13385
Andrew McGee, Sinead Prince
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引用次数: 0

摘要

作家们一直在争论生殖系基因组编辑是影响个人还是影响身份。这种差异被认为在伦理上与我们是应该选择基因组编辑还是选择植入前遗传学诊断和胚胎选择有关,当我们寻求防止或产生从编辑或选择的胚胎中生长的个体的不良状况(例如囊性纤维化或耳聋)时。我们考虑了三位杰出的生物伦理学家和哲学家最近的观点,他们一直在努力解决这个问题。我们认为双方都是正确的,但从道德上讲,当目标是生育健康的孩子时,基因编辑对人的影响意义就不那么重要了。由于这是从事胚胎选择和基因组编辑的主要目标,并且至少在目前,基因组编辑存在一定的风险,因此从道德上讲,从事胚胎选择比从事基因组编辑更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is germline genome-editing person-affecting or identity-affecting, and does it matter?

Writers have debated whether germline genome-editing is person-affecting or identity-affecting. The difference is thought to be ethically relevant to whether we should choose genome-editing or choose preimplantation genetic diagnosis and embryo selection, when seeking to prevent or produce bad conditions (e.g., cystic fibrosis, or deafness) in the individuals who will grow from the embryo edited or selected. We consider the very recent views of three prominent bioethicists and philosophers who have grappled with this issue. We claim that both sides are right, but that the sense in which genome-editing is person-affecting is less important, morally, when the aim is to have healthy children. Since this is the predominant objective of engaging in embryo selection and genome-editing, and since there are certain risks, at least for now, with genome-editing, it remains better, morally, to engage in embryo selection than genome-editing.

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来源期刊
Bioethics
Bioethics 医学-医学:伦理
CiteScore
4.20
自引率
9.10%
发文量
127
审稿时长
6-12 weeks
期刊介绍: As medical technology continues to develop, the subject of bioethics has an ever increasing practical relevance for all those working in philosophy, medicine, law, sociology, public policy, education and related fields. Bioethics provides a forum for well-argued articles on the ethical questions raised by current issues such as: international collaborative clinical research in developing countries; public health; infectious disease; AIDS; managed care; genomics and stem cell research. These questions are considered in relation to concrete ethical, legal and policy problems, or in terms of the fundamental concepts, principles and theories used in discussions of such problems. Bioethics also features regular Background Briefings on important current debates in the field. These feature articles provide excellent material for bioethics scholars, teachers and students alike.
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