关注被遗忘的细胞器：骨骼肌溶酶体的调节。

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2025-01-13 DOI:10.1249/JES.0000000000000358

Neushaw Moradi, Anastasiya Kuznyetsova, Victoria C Sanfrancesco, Sabrina Champsi, David A Hood

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引用次数: 0

摘要

摘要：骨骼肌中溶酶体作为终端细胞器在自噬和与其他细胞器通讯中的作用研究尚处于起步阶段。我们假设溶酶体可以积极适应运动，以改善肌肉内功能失调线粒体等货物的清除，代表了衰老和肌肉废用中蛋白质稳态的重要治疗方法。

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Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle.

Abstract: Research on the role of the lysosome as the terminal organelle in autophagy and in communicating with other organelles in skeletal muscle is in its infancy. We hypothesize that the lysosome can adapt positively to exercise to improve the clearance of cargo, like dysfunctional mitochondria, within muscle, representing an important therapy for protein homeostasis in aging and muscle disuse.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.