多囊卵巢综合征和分化型甲状腺癌的风险：一项基于丹麦健康数据的全国性、基于登记的队列研究

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-01-16 DOI:10.1016/j.canep.2025.102743

Clarissa L.B. Frandsen , Sarah M. Sørensen , Thomas Maltesen , Christian Munk , Ulla Feldt-Rasmussen , Allan Jensen , Susanne K. Kjær

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引用次数: 0

摘要

目的：探讨多囊卵巢综合征（PCOS）与分化型甲状腺癌和乳头状甲状腺癌的关系。方法：我们纳入了所有出生时被指定为女性和1962-1996年在丹麦出生的个体。有关生命状况、多囊卵巢综合征和癌症诊断以及协变量的信息来自丹麦各种全国登记册。所有出生时分配给所有个人的个人识别号码在所有登记册中使用，并允许准确的个人一级数据链接。采用Cox回归分析，我们根据多囊卵巢综合征的诊断，估计分化型甲状腺癌（整体甲状腺癌和单独乳头状甲状腺癌）的风险比（hr）和95% %置信区间（CI）。结果：最终的研究队列包括990850人。在随访期间，我们确定了980例偶发分化型甲状腺癌患者，其中15例先前诊断为多囊卵巢综合征。我们发现多囊卵巢综合征患者分化性甲状腺癌的发生率没有增加（HR=1.52, 95 % CI:0.91-2.53）。然而，与未患PCOS的女性相比，在PCOS诊断后10年内诊断为甲状腺癌的女性与未患PCOS的女性呈正相关（HR=3.81, 95 % CI:1.90-7.66）。值得注意的是，在多囊卵巢综合征诊断后的前三年内，没有人被诊断为分化型甲状腺癌。甲状腺乳头状癌的结果相似。结论：在调查多囊卵巢综合征与分化型和乳头状甲状腺癌之间的关系时，我们发现总体上没有相关性，尽管我们在多囊卵巢综合征诊断后的前10年确实发现了正相关。即使是这项大型研究也受到了受辐射个体中癌症病例数量较少的限制。

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Polycystic ovary syndrome and risk of differentiated thyroid cancer: A nationwide, register-based cohort study based on Danish health data

Objectives

To evaluate the association between polycystic ovary syndrome (PCOS) and the risk of differentiated and papillary thyroid cancer.

Methods

We included all individuals assigned female at birth and born during 1962–1996 in Denmark. Information on vital status, PCOS- and cancer diagnoses, and covariates were attained from various Danish nationwide registers. Personal identification numbers assigned to all individuals at birth are used throughout all registers and allows accurate individual-level data linkage. Using Cox regression analysis, we estimated hazard ratios (HRs) and 95 % confidence intervals (CI) for differentiated thyroid cancer (overall and separately for papillary thyroid cancer) according to diagnosis of PCOS.

Results

The final study cohort comprised 990 850 individuals. During follow-up, we identified 980 individuals with incident differentiated thyroid cancer, of whom 15 were previously diagnosed with PCOS. We found no increased rate of differentiated thyroid cancer for individuals with PCOS (HR=1.52, 95 % CI:0.91–2.53). However, a positive association for women diagnosed with thyroid cancer within 10 years after PCOS diagnosis (HR=3.81, 95 % CI:1.90–7.66) compared to women without PCOS was seen. Of note, none of the individuals were diagnosed with differentiated thyroid cancer within the first three years following the PCOS diagnosis. Results were similar for papillary thyroid cancer.

Conclusion

We found no association when investigating the association between PCOS and differentiated and papillary thyroid cancer overall, though we did find a positive association in the first 10 years after PCOS diagnosis. Even this large study was limited by the low number of cancer cases in exposed individuals.

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.