{"title":"多菌株年龄结构流行病模型的数值动力学与最优控制。","authors":"Zhijie Chen, Hanmeng Feng","doi":"10.1007/s00285-024-02180-y","DOIUrl":null,"url":null,"abstract":"<p><p>In this paper, a novel age-structured epidemiological model that simultaneously considers multiple viral strains is proposed. We develop a numerical framework for the study of the dynamics and optimal control by a linearly implicit Euler method, in which the biological meaning is unconditionally preserved. The first order convergence of numerical solutions in a finite time is derived from a uniform numerical boundedness. Moreover, the numerical dynamics are determined by a numerical basic reproduction number <math><msub><mi>R</mi> <mi>h</mi></msub> </math> , which reflects the asymptotic stability of the equilibrium points. The abstract framework offers an effective and unified approach to study the long-time behaviour of multi-strain epidemic models that cover a wide variety of well-known models, which also provides a numerical optimal control strategy of the multi-strain age-structured SIR model. Finally, some numerical simulations illustrate the verification and the efficiency of our results.</p>","PeriodicalId":50148,"journal":{"name":"Journal of Mathematical Biology","volume":"90 2","pages":"17"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Numerical dynamics and optimal control for multi-strain age-structured epidemic model.\",\"authors\":\"Zhijie Chen, Hanmeng Feng\",\"doi\":\"10.1007/s00285-024-02180-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this paper, a novel age-structured epidemiological model that simultaneously considers multiple viral strains is proposed. We develop a numerical framework for the study of the dynamics and optimal control by a linearly implicit Euler method, in which the biological meaning is unconditionally preserved. The first order convergence of numerical solutions in a finite time is derived from a uniform numerical boundedness. Moreover, the numerical dynamics are determined by a numerical basic reproduction number <math><msub><mi>R</mi> <mi>h</mi></msub> </math> , which reflects the asymptotic stability of the equilibrium points. The abstract framework offers an effective and unified approach to study the long-time behaviour of multi-strain epidemic models that cover a wide variety of well-known models, which also provides a numerical optimal control strategy of the multi-strain age-structured SIR model. Finally, some numerical simulations illustrate the verification and the efficiency of our results.</p>\",\"PeriodicalId\":50148,\"journal\":{\"name\":\"Journal of Mathematical Biology\",\"volume\":\"90 2\",\"pages\":\"17\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Mathematical Biology\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://doi.org/10.1007/s00285-024-02180-y\",\"RegionNum\":4,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Mathematical Biology","FirstCategoryId":"100","ListUrlMain":"https://doi.org/10.1007/s00285-024-02180-y","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Numerical dynamics and optimal control for multi-strain age-structured epidemic model.
In this paper, a novel age-structured epidemiological model that simultaneously considers multiple viral strains is proposed. We develop a numerical framework for the study of the dynamics and optimal control by a linearly implicit Euler method, in which the biological meaning is unconditionally preserved. The first order convergence of numerical solutions in a finite time is derived from a uniform numerical boundedness. Moreover, the numerical dynamics are determined by a numerical basic reproduction number , which reflects the asymptotic stability of the equilibrium points. The abstract framework offers an effective and unified approach to study the long-time behaviour of multi-strain epidemic models that cover a wide variety of well-known models, which also provides a numerical optimal control strategy of the multi-strain age-structured SIR model. Finally, some numerical simulations illustrate the verification and the efficiency of our results.
期刊介绍:
The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena.
Areas of biology covered include, but are not restricted to, cell biology, physiology, development, neurobiology, genetics and population genetics, population biology, ecology, behavioural biology, evolution, epidemiology, immunology, molecular biology, biofluids, DNA and protein structure and function. All mathematical approaches including computational and visualization approaches are appropriate.