Jin Yin, Mei Wang, Chengguo Wu, Yaling Shi, Ying Liu, Ya Yu, Qian Su, Zhengyu Zhang, Xueyong Huang, Xiaoshuang Zhang, Jun Fan, Bo Wu
{"title":"中国学校接触者中被低估的潜伏结核感染负担：一项横断面研究。","authors":"Jin Yin, Mei Wang, Chengguo Wu, Yaling Shi, Ying Liu, Ya Yu, Qian Su, Zhengyu Zhang, Xueyong Huang, Xiaoshuang Zhang, Jun Fan, Bo Wu","doi":"10.1186/s13690-025-01504-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Previous research has indicated a low tuberculin skin tests (TST) strong positive rate in school tuberculosis (TB) screening implemented by community-level medical and health care institutions in China. The research objective was to evaluate the latent tuberculosis infection (LTBI) detection gap in school contact investigation in China.</p><p><strong>Methods: </strong>In this cross-sectional study, school contacts were investigated by Chongqing Municipal Institute of Tuberculosis between January 2022 and April 2024 in Chongqing, China. TST, creation tuberculin skin test (C-TST), or Interferon-gamma release assays (IGRA) were conducted for immunological diagnostic methods. The LTBI detection gap among school contacts was assessed by comparing with the data implemented by community-level medical and health care institutions from 2021 to 2022.</p><p><strong>Results: </strong>In 6063 participants, 4233 were tested using TST, 1799 were tested using C-TST, and 31 were tested using IGRA. Seven students were confirmed to have active TB. The LTBI prevalence rate using TST and C-TST was 15.2% (95%CI, 14.1-16.3%) and 3.6% (95%CI, 2.7-4.4%) respectively. A LTBI detection gap of 10.3% was identified when comparing with TST results implemented by community-level medical and health care institutions (χ<sup>2</sup> = 636, P < 0.001).</p><p><strong>Conclusions: </strong>TB school contact investigation plays an important role in controlling TB epidemic. However, there may be a LTBI detection gap, likely due to poor quality control of TST implemented by community-level medical and health care institutions.</p>","PeriodicalId":48578,"journal":{"name":"Archives of Public Health","volume":"83 1","pages":"15"},"PeriodicalIF":3.2000,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744818/pdf/","citationCount":"0","resultStr":"{\"title\":\"Underestimated latent tuberculosis infection burden among school contacts in China: a cross-sectional study.\",\"authors\":\"Jin Yin, Mei Wang, Chengguo Wu, Yaling Shi, Ying Liu, Ya Yu, Qian Su, Zhengyu Zhang, Xueyong Huang, Xiaoshuang Zhang, Jun Fan, Bo Wu\",\"doi\":\"10.1186/s13690-025-01504-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Previous research has indicated a low tuberculin skin tests (TST) strong positive rate in school tuberculosis (TB) screening implemented by community-level medical and health care institutions in China. The research objective was to evaluate the latent tuberculosis infection (LTBI) detection gap in school contact investigation in China.</p><p><strong>Methods: </strong>In this cross-sectional study, school contacts were investigated by Chongqing Municipal Institute of Tuberculosis between January 2022 and April 2024 in Chongqing, China. TST, creation tuberculin skin test (C-TST), or Interferon-gamma release assays (IGRA) were conducted for immunological diagnostic methods. The LTBI detection gap among school contacts was assessed by comparing with the data implemented by community-level medical and health care institutions from 2021 to 2022.</p><p><strong>Results: </strong>In 6063 participants, 4233 were tested using TST, 1799 were tested using C-TST, and 31 were tested using IGRA. Seven students were confirmed to have active TB. The LTBI prevalence rate using TST and C-TST was 15.2% (95%CI, 14.1-16.3%) and 3.6% (95%CI, 2.7-4.4%) respectively. A LTBI detection gap of 10.3% was identified when comparing with TST results implemented by community-level medical and health care institutions (χ<sup>2</sup> = 636, P < 0.001).</p><p><strong>Conclusions: </strong>TB school contact investigation plays an important role in controlling TB epidemic. 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Underestimated latent tuberculosis infection burden among school contacts in China: a cross-sectional study.
Background: Previous research has indicated a low tuberculin skin tests (TST) strong positive rate in school tuberculosis (TB) screening implemented by community-level medical and health care institutions in China. The research objective was to evaluate the latent tuberculosis infection (LTBI) detection gap in school contact investigation in China.
Methods: In this cross-sectional study, school contacts were investigated by Chongqing Municipal Institute of Tuberculosis between January 2022 and April 2024 in Chongqing, China. TST, creation tuberculin skin test (C-TST), or Interferon-gamma release assays (IGRA) were conducted for immunological diagnostic methods. The LTBI detection gap among school contacts was assessed by comparing with the data implemented by community-level medical and health care institutions from 2021 to 2022.
Results: In 6063 participants, 4233 were tested using TST, 1799 were tested using C-TST, and 31 were tested using IGRA. Seven students were confirmed to have active TB. The LTBI prevalence rate using TST and C-TST was 15.2% (95%CI, 14.1-16.3%) and 3.6% (95%CI, 2.7-4.4%) respectively. A LTBI detection gap of 10.3% was identified when comparing with TST results implemented by community-level medical and health care institutions (χ2 = 636, P < 0.001).
Conclusions: TB school contact investigation plays an important role in controlling TB epidemic. However, there may be a LTBI detection gap, likely due to poor quality control of TST implemented by community-level medical and health care institutions.
期刊介绍：
rchives of Public Health is a broad scope public health journal, dedicated to publishing all sound science in the field of public health. The journal aims to better the understanding of the health of populations. The journal contributes to public health knowledge, enhances the interaction between research, policy and practice and stimulates public health monitoring and indicator development. The journal considers submissions on health outcomes and their determinants, with clear statements about the public health and policy implications. Archives of Public Health welcomes methodological papers (e.g., on study design and bias), papers on health services research, health economics, community interventions, and epidemiological studies dealing with international comparisons, the determinants of inequality in health, and the environmental, behavioural, social, demographic and occupational correlates of health and diseases.
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