厌食症女性感觉运动纹状体网络连通性的改变。

IF 3.9 2区心理学 Q1 PSYCHIATRY

European Eating Disorders Review Pub Date : 2025-01-16 DOI:10.1002/erv.3172

Yu-Ping Wang, Min-Yi Chu, Yi Wang, Xiaoxia Lei, Qing Kang, Ling Yue, Yan Chen, Simon S Y Lui, Zhen Wang, Raymond C K Chan, Jue Chen

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引用次数: 0

摘要

目的：神经性厌食症（Anorexia neurosa， AN）与奖赏加工、认知控制和身体形象感知障碍有关，可能涉及纹状体功能障碍。有证据表明，体重过轻可能会调节AN患者的脑功能。我们的目的是在控制体重不足的急性影响的同时，研究AN患者纹状体的全脑静息状态功能连接（rsFC）。方法：采用理论选择纹状体亚区，比较AN （n = 39, BMI = 16.19±1.48 kg/m2）、正常体重健康对照（n = 31, BMI = 20.98±1.72 kg/m2）和体重过轻健康对照（n = 22, BMI = 16.68±0.69 kg/m2）患者纹状体全脑rsFC模式。对AN患者的rsFC与临床指标进行相关性分析。结果：与NHC组相比，AN患者额顶叶网络纹状体rsFC增加，感觉运动区和视觉区纹状体rsFC减少。与UHC组相比，AN患者仅在感觉运动和视觉区域表现出纹状体rsFC减少。AN患者纹状体rsFC与临床变量无显著相关性。结论：我们的研究结果表明，纹状体rsFC在感觉运动区和视觉区减少可能代表了AN患者的疾病特异性神经相关因素。

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Altered Sensorimotor Striatal Network Connectivity in Women With Anorexia Nervosa.

Objective: Anorexia nervosa (AN) is associated with disturbances in reward processing, cognitive control, and body image perception, implicating striatal dysfunction. Evidence suggests that underweight may modulate brain function in AN. We aimed to investigate whole-brain resting-state functional connectivity (rsFC) of the striatum in patients with AN while controlling for the acute effects of underweight.

Method: Using theoretically selected striatal sub-regions, whole-brain rsFC patterns of the striatum were compared among patients with AN (n = 39, BMI = 16.19 ± 1.48 kg/m²), normal weight healthy controls (NHC) (n = 31, BMI = 20.98 ± 1.72 kg/m²), and underweight healthy controls (UHC) (n = 22, BMI = 16.68 ± 0.69 kg/m²). Correlation analysis between rsFC and clinical measures was conducted for the patients with AN.

Results: Compared with the NHC group, AN patients showed increased striatal rsFC with the fronto-parietal network (FPN) and reduced striatal rsFC with sensorimotor and visual regions. Compared with the UHC group, AN patients exhibited reduced striatal rsFC solely with sensorimotor and visual regions. No significant correlations were found between striatal rsFC and clinical variables in the patients with AN.

Conclusion: Our findings suggest that decreased striatal rsFC with sensorimotor and visual areas may represent illness-specific neural correlates in patients with AN.

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来源期刊

European Eating Disorders Review PSYCHOLOGY, CLINICAL-

CiteScore

8.90

自引率

7.50%

发文量

期刊介绍： European Eating Disorders Review publishes authoritative and accessible articles, from all over the world, which review or report original research that has implications for the treatment and care of people with eating disorders, and articles which report innovations and experience in the clinical management of eating disorders. The journal focuses on implications for best practice in diagnosis and treatment. The journal also provides a forum for discussion of the causes and prevention of eating disorders, and related health policy. The aims of the journal are to offer a channel of communication between researchers, practitioners, administrators and policymakers who need to report and understand developments in the field of eating disorders.