Jesús S Sánchez-Díaz, Karla G Peniche-Moguel, Diego Escarramán-Martínez, José M Reyes-Ruíz, Orlando R Pérez-Nieto
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The PaO<sub>2</sub>/FiO<sub>2</sub> ratio was measured preproning (T0), 30 min to 1 hour (T1), and 48 h after prone positioning (T2), and 30 min to 1 h after re-supination (T3).</p><p><strong>Results: </strong>The PaO<sub>2</sub>/FiO<sub>2</sub> ratio at T2 and T3 was higher in the survivors than in the non-survivors (T2= 251.5 <i>vs</i>. 208.5, <i>p</i>= 0.032; T3= 182 <i>vs</i>. 108.5, <i>p</i><0.001). The PaO<sub>2</sub>/FiO<sub>2</sub> ratio at T3 was an independent protective factor (Hazard Ratio (HR)= 0.993; 95% Confidence Interval (CI)= 0.989-0.998; <i>p</i>= 0.006) for survival. A threshold of ≤129 for the PaO<sub>2</sub>/FiO<sub>2</sub> ratio at T3 predicted non-survival with a sensitivity and specificity of 67.86 and 80.95, respectively (Area Under the Curve (AUC)= 0.782; 95% CI 0.687-0.859).</p><p><strong>Conclusion: </strong>The PaO<sub>2</sub>/FiO<sub>2</sub> ratio is a significant protective factor of survival in severe COVID-19 pneumonia within 30 min-1 hour after returning to the supine position (re-supination).</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"18 ","pages":"e18743064334878"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748056/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Protective Role of the Ratio of Arterial Partial Pressure of Oxygen and Fraction of Inspired Oxygen after Re-Supination in the Survival of Patients with Severe COVID-19 Pneumonia.\",\"authors\":\"Jesús S Sánchez-Díaz, Karla G Peniche-Moguel, Diego Escarramán-Martínez, José M Reyes-Ruíz, Orlando R Pérez-Nieto\",\"doi\":\"10.2174/0118743064334878241028114347\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The role of the ratio between the arterial partial pressure of oxygen and the inspired fraction of oxygen (PaO<sub>2</sub>/FiO<sub>2</sub> ratio) during the change in position is not fully established.</p><p><strong>Methods: </strong>This retrospective, single-center cohort study included 98 patients with severe COVID-19 pneumonia.</p><p><strong>Objective: </strong>This study aimed to evaluate the predictive value of the PaO<sub>2</sub>/FiO<sub>2</sub> ratio for survival in patients with severe COVID-19 pneumonia between changing from supine to prone positions and <i>vice versa</i>. 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引用次数: 0
摘要
背景：动脉血氧分压与吸入氧分数之比（PaO2/FiO2之比）在体位变化过程中的作用尚未完全确定。方法：回顾性、单中心队列研究纳入了98例重症COVID-19肺炎患者。目的：本研究旨在评价PaO2/FiO2比值对COVID-19重症肺炎患者仰卧位与俯卧位变化的生存预测价值。分别测定俯卧位前（T0）、俯卧位后30 min ~ 1 h （T1）、俯卧位后48 h （T2）、再旋后30 min ~ 1 h （T3）的PaO2/FiO2比值。结果：存活患者T2、T3时PaO2/FiO2比值高于非存活患者(T2= 251.5 vs. 208.5, p= 0.032；T3= 182 vs. 108.5， T3时p2/FiO2比值是独立的保护因素(危险比(HR)= 0.993；95%置信区间(CI)= 0.989 ~ 0.998；P = 0.006)。T3时PaO2/FiO2比值阈值≤129预测无生存期，敏感性和特异性分别为67.86和80.95(曲线下面积(AUC)= 0.782；95% ci 0.687-0.859)。结论：PaO2/FiO2比值是影响COVID-19重症肺炎患者仰卧位（再旋位）后30 min-1 h内存活的重要保护因素。
The Protective Role of the Ratio of Arterial Partial Pressure of Oxygen and Fraction of Inspired Oxygen after Re-Supination in the Survival of Patients with Severe COVID-19 Pneumonia.
Background: The role of the ratio between the arterial partial pressure of oxygen and the inspired fraction of oxygen (PaO2/FiO2 ratio) during the change in position is not fully established.
Methods: This retrospective, single-center cohort study included 98 patients with severe COVID-19 pneumonia.
Objective: This study aimed to evaluate the predictive value of the PaO2/FiO2 ratio for survival in patients with severe COVID-19 pneumonia between changing from supine to prone positions and vice versa. The PaO2/FiO2 ratio was measured preproning (T0), 30 min to 1 hour (T1), and 48 h after prone positioning (T2), and 30 min to 1 h after re-supination (T3).
Results: The PaO2/FiO2 ratio at T2 and T3 was higher in the survivors than in the non-survivors (T2= 251.5 vs. 208.5, p= 0.032; T3= 182 vs. 108.5, p<0.001). The PaO2/FiO2 ratio at T3 was an independent protective factor (Hazard Ratio (HR)= 0.993; 95% Confidence Interval (CI)= 0.989-0.998; p= 0.006) for survival. A threshold of ≤129 for the PaO2/FiO2 ratio at T3 predicted non-survival with a sensitivity and specificity of 67.86 and 80.95, respectively (Area Under the Curve (AUC)= 0.782; 95% CI 0.687-0.859).
Conclusion: The PaO2/FiO2 ratio is a significant protective factor of survival in severe COVID-19 pneumonia within 30 min-1 hour after returning to the supine position (re-supination).
期刊介绍：
The Open Respiratory Medicine Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in respiratory medicine. Topics covered include: -COPD- Occupational disorders, and the role of allergens and pollutants- Asthma- Allergy- Non-invasive ventilation- Therapeutic intervention- Lung cancer- Lung infections respiratory diseases- Therapeutic interventions- Adult and paediatric medicine- Cell biology. The Open Respiratory Medicine Journal, a peer reviewed journal, is an important and reliable source of current information on important recent developments in the field. The emphasis will be on publishing quality articles rapidly and making them freely available worldwide.
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