84岁女性皮肤局限性IgA血管炎1例。

Q4 Medicine
Nathan Stadem, Sara Ruter, Graison Sitenga
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引用次数: 0

摘要

IgA血管炎是一种小血管炎,虽然它代表了儿童人群中最常见的血管炎形式,但在成人中很少见。这篇手稿描述了一例皮肤有限的IgA血管炎在一个84岁的高加索女性。患者表现为双侧下肢皮疹,发生在病毒性上呼吸道疾病后大约一个月。她的皮疹最初是脚踝周围的小点斑,在一个月的时间里发展为大的汇合性瘀斑,伴有分散的点和坏死。患者因疑似血管炎接受了广泛的临床和实验室分析,结果显示血清IgA升高、中度血尿、脓尿和无症状尿路感染,但自身免疫检测结果正常。患者接受了双侧下肢皮疹的组织活检,病理提示真皮血管白细胞破裂性血管炎。肾脏病评估显示无急性肾脏病变,因此活检推迟。考虑到皮肤活检结果、血清IgA升高和之前的病毒前体症状,确诊为IgA血管炎。​完成类固醇减量治疗后,皮疹愈合良好,仅残留红斑,无紫癜复发或恶化迹象。她继续与她的医学专家进行随访,以了解潜在的全身病变,目前仍为阴性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case of Skin Limited IgA Vasculitis in an 84-Year-Old Female.

IgA vasculitis is a small vessel vasculitis and while it represents the most common form of vasculitis in pediatric populations, it is rare in adults. This manuscript describes a case of skin limited IgA vasculitis in an 84-yearold Caucasian female. The patient presented for bilateral lower extremity rash that occurred roughly one month following a viral upper respiratory illness. Her rash initially began as small petechial macules around her ankles and progressed to large confluent ecchymoses with scattered petechiae and necrosis over the course of a month. The patient underwent extensive clinical and laboratory analysis for suspected vasculitis which revealed elevated serum IgA, moderate hematuria, pyuria, and an asymptomatic urinary tract infection on urinalysis, but had otherwise normal results on autoimmune testing. The patient underwent tissues biopsies of her bilateral lower extremity rashes which revealed pathology suggestive of leukocytoclastic vasculitis of dermal vessels. Nephrology evaluation revealed no acute renal pathologies and thus biopsy was deferred. Given the result of skin biopsies, elevated serum IgA, and previous viral prodrome, the diagnosis of IgA vasculitis was confirmed. The patient was treated with 40 mg prednisone daily which was tapered over 6 weeks. Following completion of her steroid taper the rashes appeared to be healing well with only residual erythema and no signs of recurrent or worsening purpura. She continues to follow with her medical specialist for potential systemic involvement, which currently remains negative.

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CiteScore
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