Xiangning Deng, Xinyu Sui, Nan Li, Jieli Feng, Shaomin Chen, Xinye Xu, Yida Tang, Yupeng Wang
{"title":"1990年至2021年全球非风湿性钙化性主动脉瓣疾病负担的性别和年龄分布","authors":"Xiangning Deng, Xinyu Sui, Nan Li, Jieli Feng, Shaomin Chen, Xinye Xu, Yida Tang, Yupeng Wang","doi":"10.3724/zdxbyxb-2024-0610","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To analyze sex and age distribution of global disease burden of calcific aortic valve disease (CAVD) from 1990 to 2021.</p><p><strong>Methods: </strong>CAVD data during 1990-2021 were obtained from the IHME website for Global Burden of Disease (GBD). The prevalence, mortality, years lived with disability (YLDs), and disability-adjusted life years (DALYs) were analyzed by gender and age groups. Joinpoint regression was used to calculate annual percentage change (APC) and average annual percentage change (AAPC).</p><p><strong>Results: </strong>In 2021, there were 13.32 million CAVD patients and 142 000 deaths caused by CAVD globally. Age-standardized prevalence was higher in males (193.2/10<sup>5</sup>) than that in females (128.9/10<sup>5</sup>). Patients in 65-<85 age group accounted for 64.0% of total cases, while those ≥85 years old accounted for 16.1%. From 1990 to 2021, prevalence increased in both sexes with an AAPC of 0.72% for males and 0.57% for females, respectively. Prevalence grew fastest from 2000 to 2010, slowed thereafter, and declined from 2015 to 2021. In <65 years old, the mortality of males was 2.4 times higher than that of females, while in ≥85 years old, mortality of females (117.3/10<sup>5</sup>) exceeded that of males (99.1/10<sup>5</sup>). YLD rates increased with age, and were higher in males for all age groups. DALY rates decreased overall but increased in ≥85 years old, with a greater increase in females.</p><p><strong>Conclusions: </strong>There are significant gender and age disparities in global disease burden of CAVD, with the elderly, especially super-elderly females deserving particular attention. It is recommended to develop personalized intervention strategies for these populations.</p>","PeriodicalId":24007,"journal":{"name":"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences","volume":" ","pages":"21-27"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956888/pdf/","citationCount":"0","resultStr":"{\"title\":\"[Sex and age distribution of global disease burden of calcific aortic valve disease].\",\"authors\":\"Xiangning Deng, Xinyu Sui, Nan Li, Jieli Feng, Shaomin Chen, Xinye Xu, Yida Tang, Yupeng Wang\",\"doi\":\"10.3724/zdxbyxb-2024-0610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To analyze sex and age distribution of global disease burden of calcific aortic valve disease (CAVD) from 1990 to 2021.</p><p><strong>Methods: </strong>CAVD data during 1990-2021 were obtained from the IHME website for Global Burden of Disease (GBD). The prevalence, mortality, years lived with disability (YLDs), and disability-adjusted life years (DALYs) were analyzed by gender and age groups. Joinpoint regression was used to calculate annual percentage change (APC) and average annual percentage change (AAPC).</p><p><strong>Results: </strong>In 2021, there were 13.32 million CAVD patients and 142 000 deaths caused by CAVD globally. Age-standardized prevalence was higher in males (193.2/10<sup>5</sup>) than that in females (128.9/10<sup>5</sup>). Patients in 65-<85 age group accounted for 64.0% of total cases, while those ≥85 years old accounted for 16.1%. From 1990 to 2021, prevalence increased in both sexes with an AAPC of 0.72% for males and 0.57% for females, respectively. Prevalence grew fastest from 2000 to 2010, slowed thereafter, and declined from 2015 to 2021. In <65 years old, the mortality of males was 2.4 times higher than that of females, while in ≥85 years old, mortality of females (117.3/10<sup>5</sup>) exceeded that of males (99.1/10<sup>5</sup>). YLD rates increased with age, and were higher in males for all age groups. DALY rates decreased overall but increased in ≥85 years old, with a greater increase in females.</p><p><strong>Conclusions: </strong>There are significant gender and age disparities in global disease burden of CAVD, with the elderly, especially super-elderly females deserving particular attention. It is recommended to develop personalized intervention strategies for these populations.</p>\",\"PeriodicalId\":24007,\"journal\":{\"name\":\"Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. 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[Sex and age distribution of global disease burden of calcific aortic valve disease].
Objectives: To analyze sex and age distribution of global disease burden of calcific aortic valve disease (CAVD) from 1990 to 2021.
Methods: CAVD data during 1990-2021 were obtained from the IHME website for Global Burden of Disease (GBD). The prevalence, mortality, years lived with disability (YLDs), and disability-adjusted life years (DALYs) were analyzed by gender and age groups. Joinpoint regression was used to calculate annual percentage change (APC) and average annual percentage change (AAPC).
Results: In 2021, there were 13.32 million CAVD patients and 142 000 deaths caused by CAVD globally. Age-standardized prevalence was higher in males (193.2/105) than that in females (128.9/105). Patients in 65-<85 age group accounted for 64.0% of total cases, while those ≥85 years old accounted for 16.1%. From 1990 to 2021, prevalence increased in both sexes with an AAPC of 0.72% for males and 0.57% for females, respectively. Prevalence grew fastest from 2000 to 2010, slowed thereafter, and declined from 2015 to 2021. In <65 years old, the mortality of males was 2.4 times higher than that of females, while in ≥85 years old, mortality of females (117.3/105) exceeded that of males (99.1/105). YLD rates increased with age, and were higher in males for all age groups. DALY rates decreased overall but increased in ≥85 years old, with a greater increase in females.
Conclusions: There are significant gender and age disparities in global disease burden of CAVD, with the elderly, especially super-elderly females deserving particular attention. It is recommended to develop personalized intervention strategies for these populations.