糖尿病的光生物调节疗法:减轻疼痛、提高生活质量和伤口愈合的益处。

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Victória Regina da Silva Oliveira, Inaeh de Paula Oliveira, Heloísa Alonso-Matielo, Victhor Teixeira Oliveira, Jean Lucas Kremer, Milena Cristina Dias Casalverini, Fernando Quadros Ribeiro, Silvya Stuchi Maria-Engler, Silvia Romano Assis, Manoel Jacobsen Teixeira, Claudimara Ferini Pacicco Lotfi, José Pinhata Otoch, Camila Squarzoni Dale
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引用次数: 0

摘要

在全球范围内,5.37亿人患有糖尿病(DM),这种疾病通常与感觉障碍、伤口发育和慢性疼痛有关,严重影响生活质量并造成沉重的经济负担。本研究评估光生物调节(PBM)治疗对糖尿病患者伤害感受和感觉改变的影响,以了解疼痛表现,并探讨PBM对伤口愈合的分子机制。对20例2型糖尿病患者进行临床评估,完成疼痛和生活质量问卷,并采用定量感觉测试(QST)评估疼痛敏感性。取5毫米皮肤活检进行成纤维细胞培养。PBM治疗采用660 nm红光,每周2次,持续7周。结果表明,糖尿病患者存在明显的感觉障碍,影响其生活质量。PBM治疗改善疼痛评分,减轻神经性疼痛,增强感觉功能,提高生活质量,减少焦虑和抑郁。它还能加速伤口愈合,增强活动性和自主性。体外研究表明,PBM治疗通过ERK信号通路和基质金属蛋白酶(MMP-1/8和2)和金属蛋白酶组织抑制剂(TIMP)的调节增加细胞增殖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photobiomodulation therapy in diabetes: Benefits for pain relief, quality of life, and wound healing.

Globally, 537 million people suffer from diabetes mellitus (DM), a condition often associated with sensory disturbances, wound development, and chronic pain, which significantly affects the quality of life and imposes a substantial economic burden. This study evaluated the effects of photobiomodulation (PBM) therapy on nociceptive and sensory changes in diabetic patients to understand pain manifestations and explore PBM's molecular mechanisms on wound healing. Twenty patients with type 2 DM underwent clinical assessments, completed pain and quality of life questionnaires, and had their pain sensitivity evaluated using the quantitative sensory test (QST). A 5 mm skin biopsy was taken for fibroblast culture. PBM therapy, using 660 nm red light, was administered twice weekly for 7 weeks on lower limb wounds. Results indicated that DM patients faced significant sensory impairments, impacting their quality of life. PBM therapy improved pain scores, alleviated neuropathic pain, and enhanced sensory function, leading to better quality of life and reduced anxiety and depression. It also accelerated wound healing, enhancing mobility and autonomy. In vitro studies showed PBM therapy increased cell proliferation through the ERK signaling pathway and modulation of matrix metalloproteinases (MMP-1/8 and 2) and tissue inhibitors of metalloproteinases (TIMP).

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来源期刊
Photochemistry and Photobiology
Photochemistry and Photobiology 生物-生化与分子生物学
CiteScore
6.70
自引率
12.10%
发文量
171
审稿时长
2.7 months
期刊介绍: Photochemistry and Photobiology publishes original research articles and reviews on current topics in photoscience. Topics span from the primary interaction of light with molecules, cells, and tissue to the subsequent biological responses, representing disciplinary and interdisciplinary research in the fields of chemistry, physics, biology, and medicine. Photochemistry and Photobiology is the official journal of the American Society for Photobiology.
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