荆芥根中三萜皂甙及其体外抗炎活性研究。

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-01-18 DOI:10.1016/j.phytochem.2025.114403

Yueyue Lei , Dawei Xu , Yuexuan Wang , Shiwen Guo , Lujun Li , Mengyin Luo , Xu Li , Xinyi Liu , Chunyang Shi

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引用次数: 0

摘要

先前未被描述的三萜皂苷（1-8），以及8个先前报道的类似物（9-16），从从山茱萸根中获得的乙酸乙酯提取物中分离出来。通过hremsims、1D和2D NMR以及文献比较，建立了结构。所有化合物均为首次从该属植物中分离得到。在LPS诱导的RAW264.7细胞炎症模型中，化合物3-4、6-8和12-15显示出抑制NO生成的活性。此外，4、6-8和12-13在lps诱导的BV-2细胞神经炎症模型中表现出抑制作用。

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Triterpenoid saponins from Rubus setchuenensis roots and their anti-inflammatory activities in vitro

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Triterpenoid saponins from Rubus setchuenensis roots and their anti-inflammatory activities in vitro

Previously undescribed triterpenoid saponins (1–8), along with eight previously reported analogues (9–16), were isolated from an EtOAc extract obtained from the roots of Rubus setchuenensis. Structures were established based on HRESIMS, 1D and 2D NMR, as well as by literature comparisons. All compounds were isolated for the first time from the genus Rubus. Compounds 3–4, 6–8, and 12–15 displayed inhibitory activities against NO production in a RAW264.7 cell inflammation model induced by LPS. Moreover, 4, 6–8, and 12–13 exhibited inhibitory effects in a LPS-induced BV-2 cell neuroinflammation model.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.