{"title":"伊朗学龄儿童自闭症谱系障碍与碳水化合物饮食摄入之间的关系：一项病例对照研究","authors":"Shirin Tajadod, Zahra Roumi, Saheb Abbas Torki, Seyedeh Hayedeh Mousavi Shalmani, Mahdi Moradi, Zahra Saeedirad, Khadijeh Abbasi Mobarakeh, Saeideh Mohammadi, Soheila Shekari, Pouya Mirzaee, Parsa Bahmani, Anahita Houshyar-Rad, Saeid Doaei","doi":"10.1002/npr2.12521","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a neurodevelopmental disorder with both genetic and environmental risk factors. Imbalanced dietary Intake has recently been proposed as a possible environmental risk factor for ASD. The purpose of this study was to investigate the possible connection between ASD and intake of various carbohydrate types.</p><p><strong>Methods: </strong>110 patients with autism from 5 to 15 years of age have been included as the case group and 110 neurotypical children who are part of a similar age category have been chosen as controls for this case-control study. To estimate the dietary intake of carbohydrates, a validated food frequency questionnaire (FFQ) was used.</p><p><strong>Results: </strong>Positive connections were found between ASD and the intake of sugar (OR = 1.03, CI 95%: 1.02-1.06, p = 0.001), and maltose (OR = 2.09, CI 95%: 1.37-3.20, p = 0.001). A reverse correlation was found between ASD and dietary intake of carbohydrates (OR = 0.97, CI 95%: 0.96-0.98, p = 0.001), fructose (OR = 0.85, CI 95%: 0.77-0.94, p = 0.002), and lactose (OR = 0.89, CI 95%: 0.83-0.96, p = 0.002).</p><p><strong>Conclusion: </strong>This study showed a direct link between autism and the intake of sugar and maltose and an inverse connection between autism and the dietary intake of total carbohydrate, fructose, and lactose. There is a need to carry out additional long-term studies.</p>","PeriodicalId":19137,"journal":{"name":"Neuropsychopharmacology Reports","volume":"45 1","pages":"e12521"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750687/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Association Between Autism Spectrum Disorders and Dietary Intake of Carbohydrates in School-Aged Children in Iran: A Case-Control Study.\",\"authors\":\"Shirin Tajadod, Zahra Roumi, Saheb Abbas Torki, Seyedeh Hayedeh Mousavi Shalmani, Mahdi Moradi, Zahra Saeedirad, Khadijeh Abbasi Mobarakeh, Saeideh Mohammadi, Soheila Shekari, Pouya Mirzaee, Parsa Bahmani, Anahita Houshyar-Rad, Saeid Doaei\",\"doi\":\"10.1002/npr2.12521\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Autism spectrum disorder (ASD) is a neurodevelopmental disorder with both genetic and environmental risk factors. Imbalanced dietary Intake has recently been proposed as a possible environmental risk factor for ASD. The purpose of this study was to investigate the possible connection between ASD and intake of various carbohydrate types.</p><p><strong>Methods: </strong>110 patients with autism from 5 to 15 years of age have been included as the case group and 110 neurotypical children who are part of a similar age category have been chosen as controls for this case-control study. To estimate the dietary intake of carbohydrates, a validated food frequency questionnaire (FFQ) was used.</p><p><strong>Results: </strong>Positive connections were found between ASD and the intake of sugar (OR = 1.03, CI 95%: 1.02-1.06, p = 0.001), and maltose (OR = 2.09, CI 95%: 1.37-3.20, p = 0.001). A reverse correlation was found between ASD and dietary intake of carbohydrates (OR = 0.97, CI 95%: 0.96-0.98, p = 0.001), fructose (OR = 0.85, CI 95%: 0.77-0.94, p = 0.002), and lactose (OR = 0.89, CI 95%: 0.83-0.96, p = 0.002).</p><p><strong>Conclusion: </strong>This study showed a direct link between autism and the intake of sugar and maltose and an inverse connection between autism and the dietary intake of total carbohydrate, fructose, and lactose. 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引用次数: 0
摘要
背景：自闭症谱系障碍（ASD）是一种具有遗传和环境双重危险因素的神经发育障碍。膳食摄入不平衡最近被认为是自闭症的一个可能的环境风险因素。本研究的目的是探讨自闭症谱系障碍与摄入各种碳水化合物之间的可能联系。方法：110例5 ~ 15岁的自闭症患者作为病例组，110例年龄相近的神经正常儿童作为对照进行病例对照研究。为了估计饮食中碳水化合物的摄入量，使用了一种经过验证的食物频率问卷（FFQ）。结果：ASD与糖（OR = 1.03, CI 95%: 1.02-1.06, p = 0.001）和麦芽糖（OR = 2.09, CI 95%: 1.37-3.20, p = 0.001）的摄入呈正相关。ASD与饮食中碳水化合物（OR = 0.97, CI 95%: 0.96-0.98, p = 0.001）、果糖（OR = 0.85, CI 95%: 0.77-0.94, p = 0.002）和乳糖（OR = 0.89, CI 95%: 0.83-0.96, p = 0.002）的摄入呈负相关。结论：这项研究表明，自闭症与糖和麦芽糖的摄入量之间存在直接联系，而自闭症与饮食中总碳水化合物、果糖和乳糖的摄入量之间存在反比关系。有必要进行额外的长期研究。
The Association Between Autism Spectrum Disorders and Dietary Intake of Carbohydrates in School-Aged Children in Iran: A Case-Control Study.
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with both genetic and environmental risk factors. Imbalanced dietary Intake has recently been proposed as a possible environmental risk factor for ASD. The purpose of this study was to investigate the possible connection between ASD and intake of various carbohydrate types.
Methods: 110 patients with autism from 5 to 15 years of age have been included as the case group and 110 neurotypical children who are part of a similar age category have been chosen as controls for this case-control study. To estimate the dietary intake of carbohydrates, a validated food frequency questionnaire (FFQ) was used.
Results: Positive connections were found between ASD and the intake of sugar (OR = 1.03, CI 95%: 1.02-1.06, p = 0.001), and maltose (OR = 2.09, CI 95%: 1.37-3.20, p = 0.001). A reverse correlation was found between ASD and dietary intake of carbohydrates (OR = 0.97, CI 95%: 0.96-0.98, p = 0.001), fructose (OR = 0.85, CI 95%: 0.77-0.94, p = 0.002), and lactose (OR = 0.89, CI 95%: 0.83-0.96, p = 0.002).
Conclusion: This study showed a direct link between autism and the intake of sugar and maltose and an inverse connection between autism and the dietary intake of total carbohydrate, fructose, and lactose. There is a need to carry out additional long-term studies.
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