转矩病毒（TTV）感染对慢性阻塞性肺病患者临床结局、基因组完整性和死亡率的影响

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2025-01-14 DOI:10.1016/j.mad.2024.112024

Patrizia Russo , Francesca Milani , Dolores Limongi , Carla Prezioso , Federica Novazzi , Francesca Drago Ferrante , Fabrizio Maggi , Guido Antonelli , Stefano Bonassi

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引用次数: 0

摘要

简介：TTV （Torque Teno Virus）是一种病理不明确的“孤儿”病毒，与多种疾病和免疫功能障碍有关。本研究探讨重度至极重度COPD患者呼吸康复过程中TTV病毒血症与临床标志物之间的关系。方法：我们分析了102例老年COPD患者，按TTV病毒血症水平（<或≥4 log10拷贝/mL）分层。评估临床指标，包括死亡率、炎症氧化参数（淋巴细胞/单核细胞、中性粒细胞/淋巴细胞和血小板/淋巴细胞比率）、IL-6（通过ELISA测定）和DNA损伤（通过彗星测定）。结果：62.75 %的患者TTV病毒血症水平为> 4 log10拷贝/mL。没有发现电视电视水平与性或肥胖之间的联系。然而，较高的TTV病毒血症与DNA损伤增加和5年生存率显著降低相关。结论：TTV水平≥ 4 log10拷贝/mL的患者生存率最低，尽管DNA损伤是预后的一个更强的决定因素。这项研究提出了TTV在COPD中的作用的关键科学问题。具体来说，它探讨了TTV是否可以作为COPD预后不良的潜在标志物，以及这些患者的康复策略是否可以根据DNA损伤和/或病毒血症进行定制。

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The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients

Introduction

Torque Teno Virus (TTV), an "orphan" virus with unclear pathology, has been associated with various diseases and immune dysfunctions. This study investigates the link between TTV viremia and clinical markers in patients with severe to very severe COPD undergoing respiratory rehabilitation.

Methods

We analyzed 102 elderly COPD patients, stratified by TTV viremia levels (< or ≥ 4 log10 copies/mL). Clinical markers—including mortality, inflammatory-oxidative parameters (Lymphocyte/Monocyte, Neutrophil/Lymphocyte, and Platelet/Lymphocyte ratios), IL-6 (measured via ELISA assay), and DNA damage (assessed via comet assay)—were evaluated.

Results

Of the patients, 62.75 % had TTV viremia levels > 4 log₁₀ copies/mL. No associations were found between TTV levels and sex or obesity. However, higher TTV viremia correlated with increased DNA damage and significantly lower 5-year survival probability.

Conclusion

Patients with TTV levels ≥ 4 log₁₀ copies/mL exhibited the lowest survival probability, though DNA damage emerged as a stronger determinant of outcomes. This study raises key scientific questions on the role of TTV in COPD. Specifically, it explores whether TTV may serve as a potential marker for poor prognosis in COPD and whether rehabilitation strategies for these patients could be customized based on DNA damage and/or viremia.

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.